Overview
| Uniprot ID | P43686 |
|---|
| Protein Name | 26S proteasome regulatory subunit 6B |
|---|
| Gene Name | PSMC4 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 70 |
DEQKNLKKEFLHAQE |
Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides
Protein Sequence
10
MEEIGILVEK
20
AQDEIPALSV
30
SRPQTGLSFL
40
GPEPEDLEDL
50
YSRYKKLQQE
60
LEFLEVQEEY
70
IKDEQKNLKK
80
EFLHAQEEVK
90
RIQSIPLVIG
100
QFLEAVDQNT
110
AIVGSTTGSN
120
YYVRILSTID
130
RELLKPNASV
140
ALHKHSNALV
150
DVLPPEADSS
160
IMMLTSDQKP
170
DVMYADIGGM
180
DIQKQEVREA
190
VELPLTHFEL
200
YKQIGIDPPR
210
GVLMYGPPGC
220
GKTMLAKAVA
230
HHTTAAFIRV
240
VGSEFVQKYL
250
GEGPRMVRDV
260
FRLAKENAPA
270
IIFIDEIDAI
280
ATKRFDAQTG
290
ADREVQRILL
300
ELLNQMDGFD
310
QNVNVKVIMA
320
TNRADTLDPA
330
LLRPGRLDRK
340
IEFPLPDRRQ
350
KRLIFSTITS
360
KMNLSEEVDL
370
EDYVARPDKI
380
SGADINSICQ
390
ESGMLAVREN
400
RYIVLAKDFE
410
KAYKTVIKKD
EQEHEFYK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0022624 |
proteasome accessory complex |
| Cellular Component |
GO:0000502 |
proteasome complex |
| Cellular Component |
GO:0008540 |
proteasome regulatory particle, base subcomplex |
| Cellular Component |
GO:0008021 |
synaptic vesicle |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0016887 |
ATP hydrolysis activity |
| Molecular Function |
GO:0036402 |
proteasome-activating activity |
| Biological Process |
GO:0071357 |
cellular response to type I interferon |
| Biological Process |
GO:0010498 |
proteasomal protein catabolic process |
| Biological Process |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process |
GO:0006508 |
proteolysis |
| Biological Process |
GO:0061136 |
regulation of proteasomal protein catabolic process |
| Biological Process |
GO:0006979 |
response to oxidative stress |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.