Search Results
Overview
| Uniprot ID | P43897 |
|---|---|
| Protein Name | Elongation factor Ts, mitochondrial |
| Gene Name | TSFM |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 192 | QLALAIGKLGENMIL |
| 246 | ICETSEQKTNLEDVG |
| 56 | LLMKLRRKTGYSFVN |
| 76 | ETCGGDLKQAEIWLH |
| 84 | QAEIWLHKEAQKEGW |
Function
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Participates in mitochondrial translation (PubMed:27677415)
Protein Sequence
10
MSLLRSLRVF
20
LVARTGSYPA
30
GSLLRQSPQP
40
RHTFYAGPRL
50
SASASSKELL
60
MKLRRKTGYS
70
FVNCKKALET
80
CGGDLKQAEI
90
WLHKEAQKEG
100
WSKAAKLQGR
110
KTKEGLIGLL
120
QEGNTTVLVE
130
VNCETDFVSR
140
NLKFQLLVQQ
150
VALGTMMHCQ
160
TLKDQPSAYS
170
KGFLNSSELS
180
GLPAGPDREG
190
SLKDQLALAI
200
GKLGENMILK
210
RAAWVKVPSG
220
FYVGSYVHGA
230
MQSPSLHKLV
240
LGKYGALVIC
250
ETSEQKTNLE
260
DVGRRLGQHV
270
VGMAPLSVGS
280
LDDEPGGEAE
290
TKMLSQPYLL
300
DPSITLGQYV
310
QPQGVSVVDF
320
VRFECGEGEE
AAETE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005085 | guanyl-nucleotide exchange factor activity |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0003746 | translation elongation factor activity |
| Biological Process | GO:0070125 | mitochondrial translational elongation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.