Overview
| Uniprot ID | P45376 |
|---|
| Protein Name | Aldo-keto reductase family 1 member B1 |
|---|
| Gene Name | Akr1b1 |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 306 |
CALMSCAKHKDYPFH |
Function
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:17381426, PubMed:19010934, PubMed:7851421). Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides, bile acids and xenobiotics substrates (PubMed:17381426, PubMed:19010934, PubMed:7851421). It catalyzes the reduction of glucose to sorbitol, the first step of the polyol pathway, an alternative route of glucose metabolism that converts glucose to fructose. This pathway becomes highly active under elevated glucose levels, such as during hyperglycemia (By similarity). Reduces steroids and their derivatives and prostaglandins (PubMed:19010934). Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides (PubMed:17381426). Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (By similarity)
Protein Sequence
10
MASHLELNNG
20
TKMPTLGLGT
30
WKSPPGQVTE
40
AVKVAIDLGY
50
RHIDCAQVYQ
60
NEKEVGVALQ
70
EKLKEQVVKR
80
QDLFIVSKLW
90
CTFHDKSMVK
100
GAFQKTLSDL
110
QLDYLDLYLI
120
HWPTGFKPGP
130
DYFPLDASGN
140
VIPSDTDFVD
150
TWTAMEQLVD
160
EGLVKTIGVS
170
NFNPLQIERI
180
LNKPGLKYKP
190
AVNQIECHPY
200
LTQEKLIEYC
210
HSKGIVVTAY
220
SPLGSPDRPW
230
AKPEDPSLLE
240
DPRIKAIAAK
250
YNKTTAQVLI
260
RFPIQRNLVV
270
IPKSVTPVRI
280
AENLKVFDFE
290
VSSEDMATLL
300
SYNRNWRVCA
310
LMSCAKHKDY
PFHAEV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005615 |
extracellular space |
| Cellular Component |
GO:0042629 |
mast cell granule |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0033010 |
paranodal junction |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0032838 |
plasma membrane bounded cell projection cytoplasm |
| Cellular Component |
GO:0043220 |
Schmidt-Lanterman incisure |
| Cellular Component |
GO:0097454 |
Schwann cell microvillus |
| Molecular Function |
GO:0004032 |
aldose reductase (NADPH) activity |
| Molecular Function |
GO:0052650 |
all-trans-retinol dehydrogenase (NADP+) activity |
| Molecular Function |
GO:0047655 |
allyl-alcohol dehydrogenase activity |
| Molecular Function |
GO:0018505 |
cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity |
| Molecular Function |
GO:0043795 |
glyceraldehyde oxidoreductase activity |
| Molecular Function |
GO:0047956 |
glycerol dehydrogenase (NADP+) activity |
| Molecular Function |
GO:0047939 |
L-glucuronate reductase activity |
| Molecular Function |
GO:0036130 |
prostaglandin H2 endoperoxidase reductase activity |
| Molecular Function |
GO:0001758 |
retinal dehydrogenase (NAD+) activity |
| Biological Process |
GO:0071475 |
cellular hyperosmotic salinity response |
| Biological Process |
GO:0044597 |
daunorubicin metabolic process |
| Biological Process |
GO:0044598 |
doxorubicin metabolic process |
| Biological Process |
GO:0002070 |
epithelial cell maturation |
| Biological Process |
GO:0046370 |
fructose biosynthetic process |
| Biological Process |
GO:0072205 |
metanephric collecting duct development |
| Biological Process |
GO:0043066 |
negative regulation of apoptotic process |
| Biological Process |
GO:0035809 |
regulation of urine volume |
| Biological Process |
GO:0003091 |
renal water homeostasis |
| Biological Process |
GO:0001523 |
retinoid metabolic process |
| Biological Process |
GO:0006060 |
sorbitol metabolic process |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.