Search Results
Overview
| Uniprot ID | P45378 |
|---|---|
| Protein Name | Troponin T, fast skeletal muscle |
| Gene Name | TNNT3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 195 | KILAERRKPLNIDHL |
| 225 | LHQLEIDKFEFGEKL |
| 58 | RPKLTAPKIPEGEKV |
Function
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity
Protein Sequence
10
MSDEEVEQVE
20
EQYEEEEEAQ
30
EEAAEVHEEV
40
HEPEEVQEDT
50
AEEDAEEEKP
60
RPKLTAPKIP
70
EGEKVDFDDI
80
QKKRQNKDLM
90
ELQALIDSHF
100
EARKKEEEEL
110
VALKERIEKR
120
RAERAEQQRI
130
RAEKERERQN
140
RLAEEKARRE
150
EEDAKRRAED
160
DLKKKKALSS
170
MGANYSSYLA
180
KADQKRGKKQ
190
TAREMKKKIL
200
AERRKPLNID
210
HLGEDKLRDK
220
AKELWETLHQ
230
LEIDKFEFGE
240
KLKRQKYDIT
250
TLRSRIDQAQ
260
KHSKKAGTPA
KGKVGGRWK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0030172 | troponin C binding |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005861 | troponin complex |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Molecular Function | GO:0005523 | tropomyosin binding |
| Molecular Function | GO:0031013 | troponin I binding |
| Biological Process | GO:1903612 | positive regulation of calcium-dependent ATPase activity |
| Biological Process | GO:0043462 | regulation of ATP-dependent activity |
| Biological Process | GO:0006942 | regulation of striated muscle contraction |
| Biological Process | GO:0045214 | sarcomere organization |
| Biological Process | GO:0003009 | skeletal muscle contraction |
Reference
[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.
[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.