Search Results
Overview
| Uniprot ID | P45591 |
|---|---|
| Protein Name | Cofilin-2 |
| Gene Name | Cfl2 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 121 | KMIYASSKDAIKKKF |
| 22 | FNDMKVRKSSTQEEI |
Function
Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0031674 | I band |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0051015 | actin filament binding |
| Biological Process | GO:0030042 | actin filament depolymerization |
| Biological Process | GO:0030043 | actin filament fragmentation |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0051014 | actin filament severing |
| Biological Process | GO:0046716 | muscle cell cellular homeostasis |
| Biological Process | GO:0030836 | positive regulation of actin filament depolymerization |
| Biological Process | GO:0045214 | sarcomere organization |
| Biological Process | GO:0007519 | skeletal muscle tissue development |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.