Search Results
Overview
| Uniprot ID | P45592 |
|---|---|
| Protein Name | Cofilin-1 |
| Gene Name | Cfl1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 112 | APESAPLKSKMIYAS |
| 114 | ESAPLKSKMIYASSK |
| 121 | KMIYASSKDAIKKKL |
| 13 | AVSDGVIKVFNDMKV |
| 132 | KKKLTGIKHELQANC |
| 144 | ANCYEEVKDRCTLAE |
| 19 | IKVFNDMKVRKSSTP |
| 22 | FNDMKVRKSSTPEEV |
| 30 | SSTPEEVKKRKKAVL |
| 34 | EEVKKRKKAVLFCLS |
| 44 | LFCLSEDKKNIILEE |
| 45 | FCLSEDKKNIILEEG |
| 78 | FVKMLPDKDCRYALY |
| 92 | YDATYETKESKKEDL |
Function
Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (By similarity). Important for normal progress through mitosis and normal cytokinesis (By similarity). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (By similarity). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (By similarity). Required for neural tube morphogenesis and neural crest cell migration (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0031252 | cell leading edge |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0090732 | cofilin-actin rod |
| Cellular Component | GO:0030864 | cortical actin cytoskeleton |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0030175 | filopodium |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0031258 | lamellipodium membrane |
| Cellular Component | GO:0031966 | mitochondrial membrane |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0099092 | postsynaptic density, intracellular component |
| Cellular Component | GO:0032587 | ruffle membrane |
| Cellular Component | GO:0097060 | synaptic membrane |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:1902936 | phosphatidylinositol bisphosphate binding |
| Molecular Function | GO:0019903 | protein phosphatase binding |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Biological Process | GO:0030042 | actin filament depolymerization |
| Biological Process | GO:0030043 | actin filament fragmentation |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0051014 | actin filament severing |
| Biological Process | GO:0048870 | cell motility |
| Biological Process | GO:0030030 | cell projection organization |
| Biological Process | GO:0071364 | cellular response to epidermal growth factor stimulus |
| Biological Process | GO:0071362 | cellular response to ether |
| Biological Process | GO:0070301 | cellular response to hydrogen peroxide |
| Biological Process | GO:1990314 | cellular response to insulin-like growth factor stimulus |
| Biological Process | GO:0071347 | cellular response to interleukin-1 |
| Biological Process | GO:0071354 | cellular response to interleukin-6 |
| Biological Process | GO:0071356 | cellular response to tumor necrosis factor |
| Biological Process | GO:0030010 | establishment of cell polarity |
| Biological Process | GO:0051293 | establishment of spindle localization |
| Biological Process | GO:0021766 | hippocampus development |
| Biological Process | GO:0044794 | host-mediated activation of viral process |
| Biological Process | GO:0000281 | mitotic cytokinesis |
| Biological Process | GO:0098885 | modification of postsynaptic actin cytoskeleton |
| Biological Process | GO:0050804 | modulation of chemical synaptic transmission |
| Biological Process | GO:0032232 | negative regulation of actin filament bundle assembly |
| Biological Process | GO:0030835 | negative regulation of actin filament depolymerization |
| Biological Process | GO:0007162 | negative regulation of cell adhesion |
| Biological Process | GO:2000146 | negative regulation of cell motility |
| Biological Process | GO:0045792 | negative regulation of cell size |
| Biological Process | GO:1902951 | negative regulation of dendritic spine maintenance |
| Biological Process | GO:0010593 | negative regulation of lamellipodium assembly |
| Biological Process | GO:1905875 | negative regulation of postsynaptic density organization |
| Biological Process | GO:0051511 | negative regulation of unidimensional cell growth |
| Biological Process | GO:0001755 | neural crest cell migration |
| Biological Process | GO:0001842 | neural fold formation |
| Biological Process | GO:0030836 | positive regulation of actin filament depolymerization |
| Biological Process | GO:2000814 | positive regulation of barbed-end actin filament capping |
| Biological Process | GO:0030307 | positive regulation of cell growth |
| Biological Process | GO:2000147 | positive regulation of cell motility |
| Biological Process | GO:0060999 | positive regulation of dendritic spine development |
| Biological Process | GO:0040019 | positive regulation of embryonic development |
| Biological Process | GO:2000784 | positive regulation of establishment of cell polarity regulating cell shape |
| Biological Process | GO:0051894 | positive regulation of focal adhesion assembly |
| Biological Process | GO:0010592 | positive regulation of lamellipodium assembly |
| Biological Process | GO:1905873 | positive regulation of protein localization to cell leading edge |
| Biological Process | GO:0045862 | positive regulation of proteolysis |
| Biological Process | GO:0031915 | positive regulation of synaptic plasticity |
| Biological Process | GO:0006606 | protein import into nucleus |
| Biological Process | GO:0006468 | protein phosphorylation |
| Biological Process | GO:0061001 | regulation of dendritic spine morphogenesis |
| Biological Process | GO:2000310 | regulation of NMDA receptor activity |
| Biological Process | GO:0014823 | response to activity |
| Biological Process | GO:0043200 | response to amino acid |
| Biological Process | GO:0009615 | response to virus |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.