Search Results
Overview
| Uniprot ID | P45880 |
|---|---|
| Protein Name | Non-selective voltage-gated ion channel VDAC2 |
| Gene Name | VDAC2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 120 | TFSPNTGKKSGKIKS |
| 121 | FSPNTGKKSGKIKSS |
| 277 | LSALVDGKSINAGGH |
| 31 | AARDIFNKGFGFGLV |
| 72 | VTGTLETKYKWCEYG |
| 74 | GTLETKYKWCEYGLT |
Function
Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:8420959). The channel adopts an open conformation at zero mV and a closed conformation at both positive and negative potentials (PubMed:8420959). There are two populations of channels; the main that functions in a lower open-state conductance with lower ion selectivity, that switch, in a voltage-dependent manner, from the open to a low-conducting 'closed' state and the other that has a normal ion selectivity in the typical high conductance, 'open' state (PubMed:8420959). Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:31015432). Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (PubMed:31015432). Associates with the translocase of the outer mitochondrial membrane (TOM) complex and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (PubMed:40080546)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0001669 | acrosomal vesicle |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0031966 | mitochondrial membrane |
| Cellular Component | GO:0042645 | mitochondrial nucleoid |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0046930 | pore complex |
| Cellular Component | GO:0097225 | sperm midpiece |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0097001 | ceramide binding |
| Molecular Function | GO:0015485 | cholesterol binding |
| Molecular Function | GO:0008142 | oxysterol binding |
| Molecular Function | GO:0031210 | phosphatidylcholine binding |
| Molecular Function | GO:0017128 | phospholipid scramblase activity |
| Molecular Function | GO:0015288 | porin activity |
| Molecular Function | GO:0008308 | voltage-gated monoatomic anion channel activity |
| Molecular Function | GO:0005244 | voltage-gated monoatomic ion channel activity |
| Biological Process | GO:0007339 | binding of sperm to zona pellucida |
| Biological Process | GO:0097345 | mitochondrial outer membrane permeabilization |
| Biological Process | GO:1990542 | mitochondrial transmembrane transport |
| Biological Process | GO:0006820 | monoatomic anion transport |
| Biological Process | GO:0045332 | phospholipid translocation |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[4] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.
[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.