Search Results
Overview
| Uniprot ID | P45952 |
|---|---|
| Protein Name | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial |
| Gene Name | Acadm |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 179 | IKTKAEKKGDEYVIN |
| 212 | ARSNPDPKVPASKAF |
| 217 | DPKVPASKAFTGFIV |
| 236 | PGIHIGKKELNMGQR |
| 259 | FEDVRVPKENVLIGE |
| 30 | QHSKAAHKQEPGLGF |
| 301 | RALDEATKYALDRKT |
| 79 | EYPFPLIKRAWELGL |
Function
Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation (FAO), breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:16121256). The first step of FAO consists in the proR-proR stereospecific alpha, beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA) (PubMed:16121256). ETF is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase has preference for fatty acyl-CoAs with saturated 6 to 12 carbons long primary chains, making it but can also catalyze longer chains such as C14 and C16 (PubMed:16121256)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0031966 | mitochondrial membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0033011 | perinuclear theca |
| Cellular Component | GO:0120238 | sperm glycocalyx |
| Cellular Component | GO:0097228 | sperm principal piece |
| Molecular Function | GO:0003995 | acyl-CoA dehydrogenase activity |
| Molecular Function | GO:0050660 | flavin adenine dinucleotide binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0016853 | isomerase activity |
| Molecular Function | GO:0070991 | medium-chain fatty acyl-CoA dehydrogenase activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0055007 | cardiac muscle cell differentiation |
| Biological Process | GO:0045329 | carnitine biosynthetic process |
| Biological Process | GO:0009437 | carnitine metabolic process |
| Biological Process | GO:0019254 | carnitine metabolic process, CoA-linked |
| Biological Process | GO:0006635 | fatty acid beta-oxidation |
| Biological Process | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase |
| Biological Process | GO:0005978 | glycogen biosynthetic process |
| Biological Process | GO:0007507 | heart development |
| Biological Process | GO:0001889 | liver development |
| Biological Process | GO:0051793 | medium-chain fatty acid catabolic process |
| Biological Process | GO:0051791 | medium-chain fatty acid metabolic process |
| Biological Process | GO:0006082 | organic acid metabolic process |
| Biological Process | GO:0009791 | post-embryonic development |
| Biological Process | GO:0006111 | regulation of gluconeogenesis |
| Biological Process | GO:0009409 | response to cold |
| Biological Process | GO:0042594 | response to starvation |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.