Search Results

Overview

Uniprot ID	P46060
Protein Name	Ran GTPase-activating protein 1
Gene Name	RANGAP1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
26	AGGQLSFKGKSLKLN
279	GDCLVRSKGAVAIAD
28	GQLSFKGKSLKLNTA
406	QQRGQGEKSATPSRK
481	LKVSSVFKDEATVRM
524	LVHMGLLKSEDKVKA

Function

GTPase activator for RAN (PubMed:16428860, PubMed:8146159, PubMed:8896452). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:27160050, PubMed:8896452). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050)

Protein Sequence

10 MASEDIAKLA 20 ETLAKTQVAG 30 GQLSFKGKSL 40 KLNTAEDAKD 50 VIKEIEDFDS 60 LEALRLEGNT 70 VGVEAARVIA 80 KALEKKSELK 90 RCHWSDMFTG 100 RLRTEIPPAL 110 ISLGEGLITA 120 GAQLVELDLS 130 DNAFGPDGVQ 140 GFEALLKSSA 150 CFTLQELKLN 160 NCGMGIGGGK 170 ILAAALTECH 180 RKSSAQGKPL 190 ALKVFVAGRN 200 RLENDGATAL 210 AEAFRVIGTL 220 EEVHMPQNGI 230 NHPGITALAQ 240 AFAVNPLLRV 250 INLNDNTFTE 260 KGAVAMAETL 270 KTLRQVEVIN 280 FGDCLVRSKG 290 AVAIADAIRG 300 GLPKLKELNL 310 SFCEIKRDAA 320 LAVAEAMADK 330 AELEKLDLNG 340 NTLGEEGCEQ 350 LQEVLEGFNM 360 AKVLASLSDD 370 EDEEEEEEGE 380 EEEEEAEEEE 390 EEDEEEEEEE 400 EEEEEEEPQQ 410 RGQGEKSATP 420 SRKILDPNTG 430 EPAPVLSSPP 440 PADVSTFLAF 450 PSPEKLLRLG 460 PKSSVLIAQQ 470 TDTSDPEKVV 480 SAFLKVSSVF 490 KDEATVRMAV 500 QDAVDALMQK 510 AFNSSSFNSN 520 TFLTRLLVHM 530 GLLKSEDKVK 540 AIANLYGPLM 550 ALNHMVQQDY 560 FPKALAPLLL 570 AFVTKPNSAL 580 ESCSFARHSL LQTLYKV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0000776	kinetochore
Cellular Component	GO:0005635	nuclear envelope
Cellular Component	GO:0031965	nuclear membrane
Cellular Component	GO:0005643	nuclear pore
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Cellular Component	GO:0005819	spindle
Molecular Function	GO:0045296	cadherin binding
Molecular Function	GO:0005096	GTPase activator activity
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0031267	small GTPase binding
Biological Process	GO:0090630	activation of GTPase activity
Biological Process	GO:0046826	negative regulation of protein export from nucleus
Biological Process	GO:0051168	nuclear export
Biological Process	GO:0016925	protein sumoylation
Biological Process	GO:0007165	signal transduction

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.