Search Results
Overview
| Uniprot ID | P46101 |
|---|---|
| Protein Name | A-type potassium channel modulatory protein DPP6 |
| Gene Name | Dpp6 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 691 | EAVRTMLKEQYIDKT |
Function
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels (PubMed:12575952, PubMed:16123112, PubMed:19279261, PubMed:19901547). Modulates the activity and gating characteristics of the potassium channel KCND2 amd KCND3 (PubMed:12575952, PubMed:16123112, PubMed:19279261, PubMed:19901547). Promotes cell surface expression of the potassium channel KCND2 (PubMed:12575952). Has no dipeptidyl aminopeptidase activity (By similarity)
Protein Sequence
10
MASLYQRFTG
20
KINTSRSFPA
30
PPEASHLLGG
40
QGPEEDAGSK
50
PLGPQAQAVA
60
PRERGGAGGR
70
PRFQYQARSD
80
CDEEDELVGS
90
NPPQRNWKGI
100
AIALLVILVI
110
CSLIVTSVIL
120
LTPAEDTSLS
130
QKKKVTVEDL
140
FSEDFKIHDP
150
EAKWISDKEF
160
IYRERKGSVI
170
LRNVETNNST
180
VLIEGKKIES
190
LRAIRYEISP
200
DKEYALFSYN
210
VEPVYQHSHT
220
GYYVLSKIPH
230
GDPQSLDPPE
240
VSNAKLQYAG
250
WGPKGQQLIF
260
IFENNIYYCA
270
HVGKQAIRVV
280
STGKEGVIYN
290
GLSDWLYEEE
300
ILKSHIAHWW
310
SPDGTRLAYA
320
TINDSRVPLM
330
ELPTYTGSVY
340
PTVKPYHYPK
350
AGSENPSISL
360
HVIGLNGPTH
370
DLEMMPPDDP
380
RMREYYITMV
390
KWATSTKVAV
400
TWLNRAQNVS
410
ILTLCDATTG
420
VCTKKHEDES
430
EAWLHRQNEE
440
PVFSKDGRKF
450
FFVRAIPQGG
460
RGKFYHITVS
470
SSQPNSSNDN
480
IQSITSGDWD
490
VTEILTYDEK
500
RNKLYFLSTE
510
DLPRRRHLYS
520
ANTVDDFNRQ
530
CLSCDLVENC
540
TYVSASFSHN
550
MDFFLLKCEG
560
PGVPTVTVHN
570
TTDKRRMFDL
580
EANEQVQKAI
590
YDRQMPKIEY
600
RKIEVEDYSL
610
PMQILKPATF
620
TDTAHYPLLL
630
VVDGTPGSQS
640
VSERFEVTWE
650
TVLVSSHGAV
660
VVKCDGRGSG
670
FQGTKLLHEV
680
RRRLGFLEEK
690
DQMEAVRTML
700
KEQYIDKTRV
710
AVFGKDYGGY
720
LSTYILPAKG
730
ENQGQTFTCG
740
SALSPITDFK
750
LYASAFSERY
760
LGLHGLDNRA
770
YEMTKLAHRV
780
SALEDQQFLI
790
IHATADEKIH
800
FQHTAELITQ
810
LIKGKANYSL
820
QIYPDESHYF
830
HSVALKQHLY
840
RSIIGFFVEC
850
FRIQDKLPTA
TAKEDEEED
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0008076 | voltage-gated potassium channel complex |
| Molecular Function | GO:0015459 | potassium channel regulator activity |
| Molecular Function | GO:0008236 | serine-type peptidase activity |
| Biological Process | GO:0019228 | neuronal action potential |
| Biological Process | GO:1901381 | positive regulation of potassium ion transmembrane transport |
| Biological Process | GO:0043268 | positive regulation of potassium ion transport |
| Biological Process | GO:1903078 | positive regulation of protein localization to plasma membrane |
| Biological Process | GO:0072659 | protein localization to plasma membrane |
| Biological Process | GO:0006508 | proteolysis |
| Biological Process | GO:0042391 | regulation of membrane potential |
| Biological Process | GO:0060078 | regulation of postsynaptic membrane potential |
| Biological Process | GO:1901379 | regulation of potassium ion transmembrane transport |
| Biological Process | GO:0043266 | regulation of potassium ion transport |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.