Search Results
Overview
| Uniprot ID | P46109 |
|---|---|
| Protein Name | Crk-like protein |
| Gene Name | CRKL |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 189 | VRSSPHGKHGNRNSN |
| 253 | RVPCAYDKTALALEV |
Function
May mediate the transduction of intracellular signals
Protein Sequence
10
MSSARFDSSD
20
RSAWYMGPVS
30
RQEAQTRLQG
40
QRHGMFLVRD
50
SSTCPGDYVL
60
SVSENSRVSH
70
YIINSLPNRR
80
FKIGDQEFDH
90
LPALLEFYKI
100
HYLDTTTLIE
110
PAPRYPSPPM
120
GSVSAPNLPT
130
AEDNLEYVRT
140
LYDFPGNDAE
150
DLPFKKGEIL
160
VIIEKPEEQW
170
WSARNKDGRV
180
GMIPVPYVEK
190
LVRSSPHGKH
200
GNRNSNSYGI
210
PEPAHAYAQP
220
QTTTPLPAVS
230
GSPGAAITPL
240
PSTQNGPVFA
250
KAIQKRVPCA
260
YDKTALALEV
270
GDIVKVTRMN
280
INGQWEGEVN
290
GRKGLFPFTH
300
VKIFDPQNPD
ENE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0098890 | extrinsic component of postsynaptic membrane |
| Cellular Component | GO:0031594 | neuromuscular junction |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0001784 | phosphotyrosine residue binding |
| Molecular Function | GO:0030971 | receptor tyrosine kinase binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding |
| Molecular Function | GO:0035591 | signaling adaptor activity |
| Biological Process | GO:0016477 | cell migration |
| Biological Process | GO:0071560 | cellular response to transforming growth factor beta stimulus |
| Biological Process | GO:0007167 | enzyme-linked receptor protein signaling pathway |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0007254 | JNK cascade |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:0060392 | negative regulation of SMAD protein signal transduction |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:1903977 | positive regulation of glial cell migration |
| Biological Process | GO:0035022 | positive regulation of Rac protein signal transduction |
| Biological Process | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading |
| Biological Process | GO:0098698 | postsynaptic specialization assembly |
| Biological Process | GO:0007265 | Ras protein signal transduction |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.