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Overview

Uniprot IDP46199
Protein NameTranslation initiation factor IF-2, mitochondrial
Gene NameMTIF2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
383 IQRGTLRKGSVLVAG

Function

Mitochondrial translation initiation factor that promotes binding of formylmethionyl-tRNA to the 30S ribosomal subunits (By similarity). Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)

Protein Sequence

10 MNQKLLKLEN 20 LLRFHTIYRQ 30 LHSLCQRRAL 40 RQWRHGFSSA 50 YPVWTAQLCA 60 WPWPTDVLTG 70 AALSQYRLLV 80 TKKEEGPWKS 90 QLSSTKSKKV 100 VEVWIGMTIE 110 ELARAMEKNT 120 DYVYEALLNT 130 DIDIDSLEAD 140 SHLDEVWIKE 150 VITKAGMKLK 160 WSKLKQDKVR 170 KNKDAVRRPQ 180 ADPALLTPRS 190 PVVTIMGHVD 200 HGKTTLLDKF 210 RKTQVAAVET 220 GGITQHIGAF 230 LVSLPSGEKI 240 TFLDTPGHAA 250 FSAMRARGAQ 260 VTDIVVLVVA 270 ADDGVMKQTV 280 ESIQHAKDAQ 290 VPIILAVNKC 300 DKAEADPEKV 310 KKELLAYDVV 320 CEDYGGDVQA 330 VPVSALTGDN 340 LMALAEATVA 350 LAEMLELKAD 360 PNGPVEGTVI 370 ESFTDKGRGL 380 VTTAIIQRGT 390 LRKGSVLVAG 400 KCWAKVRLMF 410 DENGKTIDEA 420 YPSMPVGITG 430 WRDLPSAGEE 440 ILEVESEPRA 450 REVVDWRKYE 460 QEQEKGQEDL 470 KIIEEKRKEH 480 KEAHQKAREK 490 YGHLLWKKRS 500 ILRFLERKEQ 510 IPLKPKEKRE 520 RDSNVLSVII 530 KGDVDGSVEA 540 ILNIIDTYDA 550 SHECELELVH 560 FGVGDVSAND 570 VNLAETFDGV 580 IYGFNVNAGN 590 VIQQSAAKKG 600 VKIKLHKIIY 610 RLVEDLQEEL 620 SSRLPCAVEE 630 HPVGEASILA 640 TFSVTEGKKK 650 VPVAGCRVQK 660 GQLEKQKKFK 670 LTRNGHVIWK 680 GSLTSLKHHK 690 DDISIVKTGM 700 DCGLSLDEDN 710 MEFQVGDRIV 720 CYEEKQIQAK TSWDPGF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0043024 ribosomal small subunit binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0008135 translation factor activity, RNA binding
Molecular Function GO:0003743 translation initiation factor activity
Biological Process GO:0001731 formation of translation preinitiation complex
Biological Process GO:0070124 mitochondrial translational initiation
Biological Process GO:0032790 ribosome disassembly

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.