Search Results
Overview
| Uniprot ID | P46656 |
|---|---|
| Protein Name | Adrenodoxin, mitochondrial |
| Gene Name | Fdx1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 70 | ARSSSEDKITVHFKN |
Function
Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons
Protein Sequence
10
MAAAPGARLL
20
RAACASVPFR
30
GLDRCRLLVC
40
GTGAGTAISP
50
WTPSPRLHAE
60
AGPGRPLSVS
70
ARARSSSEDK
80
ITVHFKNRDG
90
ETLTTKGKIG
100
DSLLDVVIEN
110
NLDIDGFGAC
120
EGTLACSTCH
130
LIFEDHIYEK
140
LDAITDEEND
150
MLDLAFGLTD
160
RSRLGCQVCL
170
TKAMDNMTVR
180
VPEAVADVRQ
SVDMSKNS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030061 | mitochondrial crista |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0051537 | 2 iron, 2 sulfur cluster binding |
| Molecular Function | GO:0009055 | electron transfer activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0071320 | cellular response to cAMP |
| Biological Process | GO:1904322 | cellular response to forskolin |
| Biological Process | GO:0008203 | cholesterol metabolic process |
| Biological Process | GO:0022900 | electron transport chain |
| Biological Process | GO:0042446 | hormone biosynthetic process |
| Biological Process | GO:0140647 | P450-containing electron transport chain |
| Biological Process | GO:0051353 | positive regulation of oxidoreductase activity |
| Biological Process | GO:0050790 | regulation of catalytic activity |
| Biological Process | GO:1902031 | regulation of NADP metabolic process |
| Biological Process | GO:0006694 | steroid biosynthetic process |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.