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Overview

Uniprot IDP46734
Protein NameDual specificity mitogen-activated protein kinase kinase 3
Gene NameMAP2K3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
16 PASMPQSKGKSKRKK
80 GAYGVVEKVRHAQSG

Function

Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14

Protein Sequence

10 MESPASSQPA 20 SMPQSKGKSK 30 RKKDLRISCM 40 SKPPAPNPTP 50 PRNLDSRTFI 60 TIGDRNFEVE 70 ADDLVTISEL 80 GRGAYGVVEK 90 VRHAQSGTIM 100 AVKRIRATVN 110 SQEQKRLLMD 120 LDINMRTVDC 130 FYTVTFYGAL 140 FREGDVWICM 150 ELMDTSLDKF 160 YRKVLDKNMT 170 IPEDILGEIA 180 VSIVRALEHL 190 HSKLSVIHRD 200 VKPSNVLINK 210 EGHVKMCDFG 220 ISGYLVDSVA 230 KTMDAGCKPY 240 MAPERINPEL 250 NQKGYNVKSD 260 VWSLGITMIE 270 MAILRFPYES 280 WGTPFQQLKQ 290 VVEEPSPQLP 300 ADRFSPEFVD 310 FTAQCLRKNP 320 AERMSYLELM 330 EHPFFTLHKT 340 KKTDIAAFVK EILGEDS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016020 membrane
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0004708 MAP kinase kinase activity
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0106310 protein serine kinase activity
Molecular Function GO:0004674 protein serine/threonine kinase activity
Molecular Function GO:0004713 protein tyrosine kinase activity
Biological Process GO:0071222 cellular response to lipopolysaccharide
Biological Process GO:0072709 cellular response to sorbitol
Biological Process GO:0035924 cellular response to vascular endothelial growth factor stimulus
Biological Process GO:0090398 cellular senescence
Biological Process GO:0007507 heart development
Biological Process GO:0000165 MAPK cascade
Biological Process GO:0035331 negative regulation of hippo signaling
Biological Process GO:0038066 p38MAPK cascade
Biological Process GO:0043536 positive regulation of blood vessel endothelial cell migration
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0045860 positive regulation of protein kinase activity
Biological Process GO:0002931 response to ischemia
Biological Process GO:0007165 signal transduction
Biological Process GO:0031098 stress-activated protein kinase signaling cascade

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.