Search Results

Overview

Uniprot IDP46821
Protein NameMicrotubule-associated protein 1B
Gene NameMAP1B
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1858 LSTPGLEKDSGGKTP
1908 VGGYYYEKIERTTKS
1914 EKIERTTKSPSDSGY
1928 YSYETIGKTTKTPED
1931 ETIGKTTKTPEDGDY
1945 YSYEIIEKTTRTPEE
1976 VSGYSYEKTERSRRL
2091 LVSSCEYKHPKTELS
2278 SPKPAGLKESSDKVS
2298 KKKESVEKAAKPTTT
2333 ASASKSAKTATAGPG
506 LEGLEKLKHLDFLKQ
531 QVPTPVVKQTKLKQR
610 TEKEVPSKEEPSPVK
617 KEEPSPVKAEVAEKQ
623 VKAEVAEKQATDVKP
880 VEAYVIQKEREVTKG

Function

Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing

Protein Sequence

10 MATVVVEATE 20 PEPSGSIANP 30 AASTSPSLSH 40 RFLDSKFYLL 50 VVVGEIVTEE 60 HLRRAIGNIE 70 LGIRSWDTNL 80 IECNLDQELK 90 LFVSRHSARF 100 SPEVPGQKIL 110 HHRSDVLETV 120 VLINPSDEAV 130 STEVRLMITD 140 AARHKLLVLT 150 GQCFENTGEL 160 ILQSGSFSFQ 170 NFIEIFTDQE 180 IGELLSTTHP 190 ANKASLTLFC 200 PEEGDWKNSN 210 LDRHNLQDFI 220 NIKLNSASIL 230 PEMEGLSEFT 240 EYLSESVEVP 250 SPFDILEPPT 260 SGGFLKLSKP 270 CCYIFPGGRG 280 DSALFAVNGF 290 NMLINGGSER 300 KSCFWKLIRH 310 LDRVDSILLT 320 HIGDDNLPGI 330 NSMLQRKIAE 340 LEEEQSQGST 350 TNSDWMKNLI 360 SPDLGVVFLN 370 VPENLKNPEP 380 NIKMKRSIEE 390 ACFTLQYLNK 400 LSMKPEPLFR 410 SVGNTIDPVI 420 LFQKMGVGKL 430 EMYVLNPVKS 440 SKEMQYFMQQ 450 WTGTNKDKAE 460 FILPNGQEVD 470 LPISYLTSVS 480 SLIVWHPANP 490 AEKIIRVLFP 500 GNSTQYNILE 510 GLEKLKHLDF 520 LKQPLATQKD 530 LTGQVPTPVV 540 KQTKLKQRAD 550 SRESLKPAAK 560 PLPSKSVRKE 570 SKEETPEVTK 580 VNHVEKPPKV 590 ESKEKVMVKK 600 DKPIKTETKP 610 SVTEKEVPSK 620 EEPSPVKAEV 630 AEKQATDVKP 640 KAAKEKTVKK 650 ETKVKPEDKK 660 EEKEKPKKEV 670 AKKEDKTPIK 680 KEEKPKKEEV 690 KKEVKKEIKK 700 EEKKEPKKEV 710 KKETPPKEVK 720 KEVKKEEKKE 730 VKKEEKEPKK 740 EIKKLPKDAK 750 KSSTPLSEAK 760 KPAALKPKVP 770 KKEESVKKDS 780 VAAGKPKEKG 790 KIKVIKKEGK 800 AAEAVAAAVG 810 TGATTAAVMA 820 AAGIAAIGPA 830 KELEAERSLM 840 SSPEDLTKDF 850 EELKAEEVDV 860 TKDIKPQLEL 870 IEDEEKLKET 880 EPVEAYVIQK 890 EREVTKGPAE 900 SPDEGITTTE 910 GEGECEQTPE 920 ELEPVEKQGV 930 DDIEKFEDEG 940 AGFEESSETG 950 DYEEKAETEE 960 AEEPEEDGEE 970 HVCVSASKHS 980 PTEDEESAKA 990 EADAYIREKR 1000 ESVASGDDRA 1010 EEDMDEAIEK 1020 GEAEQSEEEA 1030 DEEDKAEDAR 1040 EEEYEPEKME 1050 AEDYVMAVVD 1060 KAAEAGGAEE 1070 QYGFLTTPTK 1080 QLGAQSPGRE 1090 PASSIHDETL 1100 PGGSESEATA 1110 SDEENREDQP 1120 EEFTATSGYT 1130 QSTIEISSEP 1140 TPMDEMSTPR 1150 DVMSDETNNE 1160 ETESPSQEFV 1170 NITKYESSLY 1180 SQEYSKPADV 1190 TPLNGFSEGS 1200 KTDATDGKDY 1210 NASASTISPP 1220 SSMEEDKFSR 1230 SALRDAYCSE 1240 VKASTTLDIK 1250 DSISAVSSEK 1260 VSPSKSPSLS 1270 PSPPSPLEKT 1280 PLGERSVNFS 1290 LTPNEIKVSA 1300 EAEVAPVSPE 1310 VTQEVVEEHC 1320 ASPEDKTLEV 1330 VSPSQSVTGS 1340 AGHTPYYQSP 1350 TDEKSSHLPT 1360 EVIEKPPAVP 1370 VSFEFSDAKD 1380 ENERASVSPM 1390 DEPVPDSESP 1400 IEKVLSPLRS 1410 PPLIGSESAY 1420 ESFLSADDKA 1430 SGRGAESPFE 1440 EKSGKQGSPD 1450 QVSPVSEMTS 1460 TSLYQDKQEG 1470 KSTDFAPIKE 1480 DFGQEKKTDD 1490 VEAMSSQPAL 1500 ALDERKLGDV 1510 SPTQIDVSQF 1520 GSFKEDTKMS 1530 ISEGTVSDKS 1540 ATPVDEGVAE 1550 DTYSHMEGVA 1560 SVSTASVATS 1570 SFPEPTTDDV 1580 SPSLHAEVGS 1590 PHSTEVDDSL 1600 SVSVVQTPTT 1610 FQETEMSPSK 1620 EECPRPMSIS 1630 PPDFSPKTAK 1640 SRTPVQDHRS 1650 EQSSMSIEFG 1660 QESPEQSLAM 1670 DFSRQSPDHP 1680 TVGAGVLHIT 1690 ENGPTEVDYS 1700 PSDMQDSSLS 1710 HKIPPMEEPS 1720 YTQDNDLSEL 1730 ISVSQVEASP 1740 STSSAHTPSQ 1750 IASPLQEDTL 1760 SDVAPPRDMS 1770 LYASLTSEKV 1780 QSLEGEKLSP 1790 KSDISPLTPR 1800 ESSPLYSPTF 1810 SDSTSAVKEK 1820 TATCHSSSSP 1830 PIDAASAEPY 1840 GFRASVLFDT 1850 MQHHLALNRD 1860 LSTPGLEKDS 1870 GGKTPGDFSY 1880 AYQKPEETTR 1890 SPDEEDYDYE 1900 SYEKTTRTSD 1910 VGGYYYEKIE 1920 RTTKSPSDSG 1930 YSYETIGKTT 1940 KTPEDGDYSY 1950 EIIEKTTRTP 1960 EEGGYSYDIS 1970 EKTTSPPEVS 1980 GYSYEKTERS 1990 RRLLDDISNG 2000 YDDSEDGGHT 2010 LGDPSYSYET 2020 TEKITSFPES 2030 EGYSYETSTK 2040 TTRTPDTSTY 2050 CYETAEKITR 2060 TPQASTYSYE 2070 TSDLCYTAEK 2080 KSPSEARQDV 2090 DLCLVSSCEY 2100 KHPKTELSPS 2110 FINPNPLEWF 2120 ASEEPTEESE 2130 KPLTQSGGAP 2140 PPPGGKQQGR 2150 QCDETPPTSV 2160 SESAPSQTDS 2170 DVPPETEECP 2180 SITADANIDS 2190 EDESETIPTD 2200 KTVTYKHMDP 2210 PPAPVQDRSP 2220 SPRHPDVSMV 2230 DPEALAIEQN 2240 LGKALKKDLK 2250 EKTKTKKPGT 2260 KTKSSSPVKK 2270 SDGKSKPLAA 2280 SPKPAGLKES 2290 SDKVSRVASP 2300 KKKESVEKAA 2310 KPTTTPEVKA 2320 ARGEEKDKET 2330 KNAANASASK 2340 SAKTATAGPG 2350 TTKTTKSSAV 2360 PPGLPVYLDL 2370 CYIPNHSNSK 2380 NVDVEFFKRV 2390 RSSYYVVSGN 2400 DPAAEEPSRA 2410 VLDALLEGKA 2420 QWGSNMQVTL 2430 IPTHDSEVMR 2440 EWYQETHEKQ 2450 QDLNIMVLAS 2460 SSTVVMQDES FPACKIEL

Gene Ontology

Classification GO ID Description
Biological Process GO:0032355 response to estradiol
Cellular Component GO:0097440 apical dendrite
Cellular Component GO:0030424 axon
Cellular Component GO:0097441 basal dendrite
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030425 dendrite
Cellular Component GO:0043197 dendritic spine
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0030426 growth cone
Cellular Component GO:0097457 hippocampal mossy fiber
Cellular Component GO:0005874 microtubule
Cellular Component GO:0005875 microtubule associated complex
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0043204 perikaryon
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0001750 photoreceptor outer segment
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0014069 postsynaptic density
Cellular Component GO:0036477 somatodendritic compartment
Cellular Component GO:0045202 synapse
Cellular Component GO:0043196 varicosity
Molecular Function GO:0003779 actin binding
Molecular Function GO:0008017 microtubule binding
Molecular Function GO:0005543 phospholipid binding
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0048675 axon extension
Biological Process GO:0007409 axonogenesis
Biological Process GO:0071363 cellular response to growth factor stimulus
Biological Process GO:0071375 cellular response to peptide hormone stimulus
Biological Process GO:0016358 dendrite development
Biological Process GO:0021700 developmental maturation
Biological Process GO:0051915 induction of synaptic plasticity by chemical substance
Biological Process GO:0001578 microtubule bundle formation
Biological Process GO:0000226 microtubule cytoskeleton organization
Biological Process GO:0007026 negative regulation of microtubule depolymerization
Biological Process GO:0001764 neuron migration
Biological Process GO:0031175 neuron projection development
Biological Process GO:0071895 odontoblast differentiation
Biological Process GO:0014012 peripheral nervous system axon regeneration
Biological Process GO:0045773 positive regulation of axon extension
Biological Process GO:0031116 positive regulation of microtubule polymerization
Biological Process GO:0045666 positive regulation of neuron differentiation
Biological Process GO:0031114 regulation of microtubule depolymerization
Biological Process GO:0150052 regulation of postsynapse assembly
Biological Process GO:0009743 response to carbohydrate
Biological Process GO:0017085 response to insecticide
Biological Process GO:0009612 response to mechanical stimulus
Biological Process GO:0033189 response to vitamin A
Biological Process GO:0009410 response to xenobiotic stimulus
Biological Process GO:0007416 synapse assembly

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.