Search Results
Overview
| Uniprot ID | P46821 |
|---|---|
| Protein Name | Microtubule-associated protein 1B |
| Gene Name | MAP1B |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1858 | LSTPGLEKDSGGKTP |
| 1908 | VGGYYYEKIERTTKS |
| 1914 | EKIERTTKSPSDSGY |
| 1928 | YSYETIGKTTKTPED |
| 1931 | ETIGKTTKTPEDGDY |
| 1945 | YSYEIIEKTTRTPEE |
| 1976 | VSGYSYEKTERSRRL |
| 2091 | LVSSCEYKHPKTELS |
| 2278 | SPKPAGLKESSDKVS |
| 2298 | KKKESVEKAAKPTTT |
| 2333 | ASASKSAKTATAGPG |
| 506 | LEGLEKLKHLDFLKQ |
| 531 | QVPTPVVKQTKLKQR |
| 610 | TEKEVPSKEEPSPVK |
| 617 | KEEPSPVKAEVAEKQ |
| 623 | VKAEVAEKQATDVKP |
| 880 | VEAYVIQKEREVTKG |
Function
Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0032355 | response to estradiol |
| Cellular Component | GO:0097440 | apical dendrite |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0097441 | basal dendrite |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0097457 | hippocampal mossy fiber |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0005875 | microtubule associated complex |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0001750 | photoreceptor outer segment |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0036477 | somatodendritic compartment |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0043196 | varicosity |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0005543 | phospholipid binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0005198 | structural molecule activity |
| Biological Process | GO:0048675 | axon extension |
| Biological Process | GO:0007409 | axonogenesis |
| Biological Process | GO:0071363 | cellular response to growth factor stimulus |
| Biological Process | GO:0071375 | cellular response to peptide hormone stimulus |
| Biological Process | GO:0016358 | dendrite development |
| Biological Process | GO:0021700 | developmental maturation |
| Biological Process | GO:0051915 | induction of synaptic plasticity by chemical substance |
| Biological Process | GO:0001578 | microtubule bundle formation |
| Biological Process | GO:0000226 | microtubule cytoskeleton organization |
| Biological Process | GO:0007026 | negative regulation of microtubule depolymerization |
| Biological Process | GO:0001764 | neuron migration |
| Biological Process | GO:0031175 | neuron projection development |
| Biological Process | GO:0071895 | odontoblast differentiation |
| Biological Process | GO:0014012 | peripheral nervous system axon regeneration |
| Biological Process | GO:0045773 | positive regulation of axon extension |
| Biological Process | GO:0031116 | positive regulation of microtubule polymerization |
| Biological Process | GO:0045666 | positive regulation of neuron differentiation |
| Biological Process | GO:0031114 | regulation of microtubule depolymerization |
| Biological Process | GO:0150052 | regulation of postsynapse assembly |
| Biological Process | GO:0009743 | response to carbohydrate |
| Biological Process | GO:0017085 | response to insecticide |
| Biological Process | GO:0009612 | response to mechanical stimulus |
| Biological Process | GO:0033189 | response to vitamin A |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0007416 | synapse assembly |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.