Overview
| Uniprot ID | P46926 |
|---|
| Protein Name | Glucosamine-6-phosphate deaminase 1 |
|---|
| Gene Name | GNPDA1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 160 |
LVSRTRVKTLAMDTI |
Function
Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis (PubMed:21807125, PubMed:26887390). Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling (PubMed:26887390). Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity)
Protein Sequence
10
MKLIILEHYS
20
QASEWAAKYI
30
RNRIIQFNPG
40
PEKYFTLGLP
50
TGSTPLGCYK
60
KLIEYYKNGD
70
LSFKYVKTFN
80
MDEYVGLPRD
90
HPESYHSFMW
100
NNFFKHIDIH
110
PENTHILDGN
120
AVDLQAECDA
130
FEEKIKAAGG
140
IELFVGGIGP
150
DGHIAFNEPG
160
SSLVSRTRVK
170
TLAMDTILAN
180
ARFFDGELTK
190
VPTMALTVGV
200
GTVMDAREVM
210
ILITGAHKAF
220
ALYKAIEEGV
230
NHMWTVSAFQ
240
QHPRTVFVCD
250
EDATLELKVK
260
TVKYFKGLML
270
VHNKLVDPLY
280
SIKEKETEKS
QSSKKPYSD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Molecular Function |
GO:0004342 |
glucosamine-6-phosphate deaminase activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0016853 |
isomerase activity |
| Biological Process |
GO:0005975 |
carbohydrate metabolic process |
| Biological Process |
GO:0006091 |
generation of precursor metabolites and energy |
| Biological Process |
GO:0006043 |
glucosamine catabolic process |
| Biological Process |
GO:0006046 |
N-acetylglucosamine catabolic process |
| Biological Process |
GO:0019262 |
N-acetylneuraminate catabolic process |
| Biological Process |
GO:0007338 |
single fertilization |
| Biological Process |
GO:0006048 |
UDP-N-acetylglucosamine biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.