Search Results
Overview
| Uniprot ID | P46937 |
|---|---|
| Protein Name | Transcriptional coactivator YAP1 |
| Gene Name | YAP1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 321 | EKERLRLKQQELLRQ |
| 342 | PSTANSPKCQELALR |
| 90 | TVPMRLRKLPDSFFK |
Function
Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005923 | bicellular tight junction |
| Molecular Function | GO:0003712 | transcription coregulator activity |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Biological Process | GO:0061026 | cardiac muscle tissue regeneration |
| Biological Process | GO:0071480 | cellular response to gamma radiation |
| Biological Process | GO:0006974 | DNA damage response |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0050673 | epithelial cell proliferation |
| Biological Process | GO:0003015 | heart process |
| Biological Process | GO:0035329 | hippo signaling |
| Biological Process | GO:0070102 | interleukin-6-mediated signaling pathway |
| Biological Process | GO:0060576 | intestinal epithelial cell development |
| Biological Process | GO:1902018 | negative regulation of cilium assembly |
| Biological Process | GO:1904036 | negative regulation of epithelial cell apoptotic process |
| Biological Process | GO:0045599 | negative regulation of fat cell differentiation |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0035265 | organ growth |
| Biological Process | GO:0030859 | polarized epithelial cell differentiation |
| Biological Process | GO:0060045 | positive regulation of cardiac muscle cell proliferation |
| Biological Process | GO:0030307 | positive regulation of cell growth |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0050679 | positive regulation of epithelial cell proliferation |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0045747 | positive regulation of Notch signaling pathway |
| Biological Process | GO:0045669 | positive regulation of osteoblast differentiation |
| Biological Process | GO:1900182 | positive regulation of protein localization to nucleus |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0065003 | protein-containing complex assembly |
| Biological Process | GO:0050767 | regulation of neurogenesis |
| Biological Process | GO:0072091 | regulation of stem cell proliferation |
| Biological Process | GO:0032570 | response to progesterone |
| Biological Process | GO:0001894 | tissue homeostasis |
| Biological Process | GO:0042060 | wound healing |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0140552 | TEAD-YAP complex |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0140297 | DNA-binding transcription factor binding |
| Molecular Function | GO:0070064 | proline-rich region binding |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0000976 | transcription cis-regulatory region binding |
| Molecular Function | GO:0003713 | transcription coactivator activity |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.