Search Results
Overview
| Uniprot ID | P46952 |
|---|---|
| Protein Name | 3-hydroxyanthranilate 3,4-dioxygenase |
| Gene Name | HAAO |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 12 | LGVRAWVKENRGSFQ |
| 158 | SEQYRTGKPIPDQLL |
| 282 | VTQDPACKKPLG*** |
| 71 | LRVLEQGKHRDVVIR |
Function
Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate
Protein Sequence
10
MERRLGVRAW
20
VKENRGSFQP
30
PVCNKLMHQE
40
QLKVMFIGGP
50
NTRKDYHIEE
60
GEEVFYQLEG
70
DMVLRVLEQG
80
KHRDVVIRQG
90
EIFLLPARVP
100
HSPQRFANTV
110
GLVVERRRLE
120
TELDGLRYYV
130
GDTMDVLFEK
140
WFYCKDLGTQ
150
LAPIIQEFFS
160
SEQYRTGKPI
170
PDQLLKEPPF
180
PLSTRSIMEP
190
MSLDAWLDSH
200
HRELQAGTPL
210
SLFGDTYETQ
220
VIAYGQGSSE
230
GLRQNVDVWL
240
WQLEGSSVVT
250
MGGRRLSLAP
260
DDSLLVLAGT
270
SYAWERTQGS
280
VALSVTQDPA
CKKPLG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0000334 | 3-hydroxyanthranilate 3,4-dioxygenase activity |
| Molecular Function | GO:0009055 | electron transfer activity |
| Molecular Function | GO:0008198 | ferrous iron binding |
| Biological Process | GO:0034354 | 'de novo' NAD+ biosynthetic process from L-tryptophan |
| Biological Process | GO:0043420 | anthranilate metabolic process |
| Biological Process | GO:0006569 | L-tryptophan catabolic process |
| Biological Process | GO:0009435 | NAD+ biosynthetic process |
| Biological Process | GO:0070050 | neuron cellular homeostasis |
| Biological Process | GO:0019805 | quinolinate biosynthetic process |
| Biological Process | GO:0046874 | quinolinate metabolic process |
| Biological Process | GO:0046686 | response to cadmium ion |
| Biological Process | GO:0010043 | response to zinc ion |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.