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Overview

Uniprot ID	P46976
Protein Name	Glycogenin-1
Gene Name	GYG1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
27	LVLGSSLKQHRTTRR
344	SFDNIKRKLDTYLQ*

Function

Glycogenin participates in the glycogen biosynthetic process along with glycogen synthase and glycogen branching enzyme. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase

Protein Sequence

10 MTDQAFVTLT 20 TNDAYAKGAL 30 VLGSSLKQHR 40 TTRRLVVLAT 50 PQVSDSMRKV 60 LETVFDEVIM 70 VDVLDSGDSA 80 HLTLMKRPEL 90 GVTLTKLHCW 100 SLTQYSKCVF 110 MDADTLVLAN 120 IDDLFDREEL 130 SAAPDPGWPD 140 CFNSGVFVYQ 150 PSVETYNQLL 160 HLASEQGSFD 170 GGDQGILNTF 180 FSSWATTDIR 190 KHLPFIYNLS 200 SISIYSYLPA 210 FKVFGASAKV 220 VHFLGRVKPW 230 NYTYDPKTKS 240 VKSEAHDPNM 250 THPEFLILWW 260 NIFTTNVLPL 270 LQQFGLVKDT 280 CSYVNVLSDL 290 VYTLAFSCGF 300 CRKEDVSGAI 310 SHLSLGEIPA 320 MAQPFVSSEE 330 RKERWEQGQA 340 DYMGADSFDN 350 IKRKLDTYLQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:1904813	ficolin-1-rich granule lumen
Cellular Component	GO:0043202	lysosomal lumen
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0034774	secretory granule lumen
Molecular Function	GO:0008466	glycogenin glucosyltransferase activity
Molecular Function	GO:0030145	manganese ion binding
Molecular Function	GO:0042803	protein homodimerization activity
Biological Process	GO:0005978	glycogen biosynthetic process
Biological Process	GO:0160249	glycogen biosynthetic process via UDP-glucose

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.