Overview
| Uniprot ID | P47727 |
|---|
| Protein Name | Carbonyl reductase [NADPH] 1 |
|---|
| Gene Name | Cbr1 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 148 |
SVSLRALKSCSPELQ |
Function
NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics (PubMed:7705364, PubMed:8198567). Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (By similarity). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue (By similarity)
Protein Sequence
10
MSSDRPVALV
20
TGANKGIGFA
30
IVRDLCRKFL
40
GDVVLTARDE
50
SRGHEAVKQL
60
QTEGLSPRFH
70
QLDIDNPQSI
80
RALRDFLLQE
90
YGGLNVLVNN
100
AGIAFKVVDP
110
TPFHIQAEVT
120
MKTNFFGTQD
130
VCKELLPIIK
140
PQGRVVNVSS
150
SVSLRALKSC
160
SPELQQKFRS
170
ETITEEELVG
180
LMNKFIEDAK
190
KGVHAKEGWP
200
NSAYGVTKIG
210
VTVLSRIYAR
220
KLNEERREDK
230
ILLNACCPGW
240
VRTDMAGPKA
250
TKSPEEGAET
260
PVYLALLPPG
270
AEGPHGQFVQ
DKKVEPW
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005902 |
microvillus |
| Molecular Function |
GO:0047021 |
15-hydroxyprostaglandin dehydrogenase (NADP+) activity |
| Molecular Function |
GO:0047020 |
15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity |
| Molecular Function |
GO:0004090 |
carbonyl reductase (NADPH) activity |
| Molecular Function |
GO:0016655 |
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor |
| Molecular Function |
GO:0016616 |
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| Molecular Function |
GO:0050221 |
prostaglandin E2 9-reductase activity |
| Molecular Function |
GO:0160163 |
S-nitrosoglutathione reductase (NADPH) activity |
| Biological Process |
GO:0030855 |
epithelial cell differentiation |
| Biological Process |
GO:0008211 |
glucocorticoid metabolic process |
| Biological Process |
GO:0001542 |
ovulation from ovarian follicle |
| Biological Process |
GO:0042376 |
phylloquinone catabolic process |
| Biological Process |
GO:2000379 |
positive regulation of reactive oxygen species metabolic process |
| Biological Process |
GO:1905344 |
prostaglandin catabolic process |
| Biological Process |
GO:0032355 |
response to estradiol |
| Biological Process |
GO:0034698 |
response to gonadotropin |
| Biological Process |
GO:0032496 |
response to lipopolysaccharide |
| Biological Process |
GO:0032570 |
response to progesterone |
| Biological Process |
GO:0033574 |
response to testosterone |
| Biological Process |
GO:0006706 |
steroid catabolic process |
| Biological Process |
GO:0042373 |
vitamin K metabolic process |
| Biological Process |
GO:0006805 |
xenobiotic metabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.