Search Results

Overview

Uniprot IDP47728
Protein NameCalretinin
Gene NameCalb2
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
142 FLSDLLKKANRPYDE
233 DLYEKNKKEMNIQQL
245 QQLTTYRKSVMSLAE
60 KGSGMMSKSDNFGEK

Function

Calcium-binding protein involved in calcium homeostasis and signal transduction. It plays a critical role in buffering intracellular calcium levels and modulating calcium-dependent signaling pathways. Predominantly expressed in specific neuronal populations, influences synaptic plasticity and neuronal excitability, contributing to learning and memory (By similarity). During embryonic development, it facilitates neuronal differentiation and maturation (PubMed:14664811)

Protein Sequence

10 MAGPQQQPPY 20 LHLAELTASQ 30 FLEIWKHFDA 40 DGNGYIEGKE 50 LENFFQELEK 60 ARKGSGMMSK 70 SDNFGEKMKE 80 FMQKYDKNSD 90 GKIEMAELAQ 100 ILPTEENFLL 110 CFRQHVGSSA 120 EFMEAWRKYD 130 TDRSGYIEAN 140 ELKGFLSDLL 150 KKANRPYDEP 160 KLQEYTQTIL 170 RMFDLNGDGK 180 LGLSEMSRLL 190 PVQENFLLKF 200 QGMKLTSEEF 210 NAIFTFYDKD 220 GSGYIDENEL 230 DALLKDLYEK 240 NKKEMNIQQL 250 TTYRKSVMSL 260 AEAGKLYRKD 270 LEIVLCSEPP M

Gene Ontology

Classification GO ID Description
Cellular Component GO:0032437 cuticular plate
Cellular Component GO:0005829 cytosol
Cellular Component GO:0044293 dendriole
Cellular Component GO:0030425 dendrite
Cellular Component GO:0005921 gap junction
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0005634 nucleus
Cellular Component GO:0098688 parallel fiber to Purkinje cell synapse
Cellular Component GO:0032420 stereocilium
Cellular Component GO:0045202 synapse
Cellular Component GO:0043195 terminal bouton
Cellular Component GO:0099096 vestibular calyx terminal
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0099534 calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration
Biological Process GO:0006874 intracellular calcium ion homeostasis
Biological Process GO:0048167 regulation of synaptic plasticity
Biological Process GO:0099536 synaptic signaling

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.