Search Results
Overview
| Uniprot ID | P47738 |
|---|---|
| Protein Name | Aldehyde dehydrogenase, mitochondrial |
| Gene Name | Aldh2 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 370 | QVDETQFKKILGYIK |
| 377 | KKILGYIKSGQQEGA |
| 385 | SGQQEGAKLLCGGGA |
| 430 | VMQILKFKTIEEVVG |
| 513 | EVKTVTVKVPQKNS* |
Function
Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage
Protein Sequence
10
MLRAALTTVR
20
RGPRLSRLLS
30
AAATSAVPAP
40
NHQPEVFCNQ
50
IFINNEWHDA
60
VSRKTFPTVN
70
PSTGEVICQV
80
AEGNKEDVDK
90
AVKAARAAFQ
100
LGSPWRRMDA
110
SDRGRLLYRL
120
ADLIERDRTY
130
LAALETLDNG
140
KPYVISYLVD
150
LDMVLKCLRY
160
YAGWADKYHG
170
KTIPIDGDFF
180
SYTRHEPVGV
190
CGQIIPWNFP
200
LLMQAWKLGP
210
ALATGNVVVM
220
KVAEQTPLTA
230
LYVANLIKEA
240
GFPPGVVNIV
250
PGFGPTAGAA
260
IASHEGVDKV
270
AFTGSTEVGH
280
LIQVAAGSSN
290
LKRVTLELGG
300
KSPNIIMSDA
310
DMDWAVEQAH
320
FALFFNQGQC
330
CCAGSRTFVQ
340
ENVYDEFVER
350
SVARAKSRVV
360
GNPFDSRTEQ
370
GPQVDETQFK
380
KILGYIKSGQ
390
QEGAKLLCGG
400
GAAADRGYFI
410
QPTVFGDVKD
420
GMTIAKEEIF
430
GPVMQILKFK
440
TIEEVVGRAN
450
DSKYGLAAAV
460
FTKDLDKANY
470
LSQALQAGTV
480
WINCYDVFGA
490
QSPFGGYKMS
500
GSGRELGEYG
510
LQAYTEVKTV
TVKVPQKNS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0006068 | ethanol catabolic process |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004029 | aldehyde dehydrogenase (NAD+) activity |
| Molecular Function | GO:0106435 | carboxylesterase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0051287 | NAD binding |
| Molecular Function | GO:0070404 | NADH binding |
| Molecular Function | GO:0008957 | phenylacetaldehyde dehydrogenase (NAD+) activity |
| Biological Process | GO:0006117 | acetaldehyde metabolic process |
| Biological Process | GO:0046185 | aldehyde catabolic process |
| Biological Process | GO:0048149 | behavioral response to ethanol |
| Biological Process | GO:0110095 | cellular detoxification of aldehyde |
| Biological Process | GO:0006067 | ethanol metabolic process |
| Biological Process | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0018937 | nitroglycerin metabolic process |
| Biological Process | GO:1903179 | regulation of dopamine biosynthetic process |
| Biological Process | GO:2000377 | regulation of reactive oxygen species metabolic process |
| Biological Process | GO:1905627 | regulation of serotonin biosynthetic process |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.
[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.