Search Results

Overview

Uniprot IDP47755
Protein NameF-actin-capping protein subunit alpha-2
Gene NameCAPZA2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
166 ESHQFQAKNFWNGRW
268 QLPVTRTKIDWNKIL
278 WNKILSYKIGKEMQN
86 HGDLGNGKFLDPKNR
97 PKNRICFKFDHLRKE

Function

F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments

Protein Sequence

10 MADLEEQLSD 20 EEKVRIAAKF 30 IIHAPPGEFN 40 EVFNDVRLLL 50 NNDNLLREGA 60 AHAFAQYNLD 70 QFTPVKIEGY 80 EDQVLITEHG 90 DLGNGKFLDP 100 KNRICFKFDH 110 LRKEATDPRP 120 CEVENAVESW 130 RTSVETALRA 140 YVKEHYPNGV 150 CTVYGKKIDG 160 QQTIIACIES 170 HQFQAKNFWN 180 GRWRSEWKFT 190 ITPSTTQVVG 200 ILKIQVHYYE 210 DGNVQLVSHK 220 DIQDSLTVSN 230 EVQTAKEFIK 240 IVEAAENEYQ 250 TAISENYQTM 260 SDTTFKALRR 270 QLPVTRTKID 280 WNKILSYKIG KEMQNA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005903 brush border
Cellular Component GO:0030863 cortical cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0008290 F-actin capping protein complex
Cellular Component GO:0016020 membrane
Molecular Function GO:0051015 actin filament binding
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0051016 barbed-end actin filament capping
Biological Process GO:0065003 protein-containing complex assembly

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.