Search Results

Overview

Uniprot IDP47756
Protein NameF-actin-capping protein subunit beta
Gene NameCAPZB
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
235 LNEIYFGKTKDIVNG
237 EIYFGKTKDIVNGLR
267 NDLVEALKRKQQC**
57 ARDKVVGKDYLLCDY
95 MPSARLRKLEVEANN

Function

F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity)

Protein Sequence

10 MSDQQLDCAL 20 DLMRRLPPQQ 30 IEKNLSDLID 40 LVPSLCEDLL 50 SSVDQPLKIA 60 RDKVVGKDYL 70 LCDYNRDGDS 80 YRSPWSNKYD 90 PPLEDGAMPS 100 ARLRKLEVEA 110 NNAFDQYRDL 120 YFEGGVSSVY 130 LWDLDHGFAG 140 VILIKKAGDG 150 SKKIKGCWDS 160 IHVVEVQEKS 170 SGRTAHYKLT 180 STVMLWLQTN 190 KSGSGTMNLG 200 GSLTRQMEKD 210 ETVSDCSPHI 220 ANIGRLVEDM 230 ENKIRSTLNE 240 IYFGKTKDIV 250 NGLRSVQTFA 260 DKSKQEALKN 270 DLVEALKRKQ QC

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005903 brush border
Cellular Component GO:0030863 cortical cytoskeleton
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0008290 F-actin capping protein complex
Cellular Component GO:0098686 hippocampal mossy fiber to CA3 synapse
Cellular Component GO:0030027 lamellipodium
Cellular Component GO:0016020 membrane
Cellular Component GO:0014069 postsynaptic density
Cellular Component GO:0030017 sarcomere
Cellular Component GO:0098685 Schaffer collateral - CA1 synapse
Cellular Component GO:0120212 sperm head-tail coupling apparatus
Cellular Component GO:0071203 WASH complex
Molecular Function GO:0003779 actin binding
Molecular Function GO:0045296 cadherin binding
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0051016 barbed-end actin filament capping

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[5] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.