Search Results
Overview
| Uniprot ID | P47757 |
|---|---|
| Protein Name | F-actin-capping protein subunit beta |
| Gene Name | Capzb |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 254 | DAIPDNHKFKQLQRE |
Function
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005903 | brush border |
| Cellular Component | GO:0030863 | cortical cytoskeleton |
| Cellular Component | GO:0033150 | cytoskeletal calyx |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0008290 | F-actin capping protein complex |
| Cellular Component | GO:0098686 | hippocampal mossy fiber to CA3 synapse |
| Cellular Component | GO:0014704 | intercalated disc |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Cellular Component | GO:0061827 | sperm head |
| Cellular Component | GO:0120212 | sperm head-tail coupling apparatus |
| Cellular Component | GO:0071203 | WASH complex |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0048487 | beta-tubulin binding |
| Biological Process | GO:0008154 | actin polymerization or depolymerization |
| Biological Process | GO:1990051 | activation of protein kinase C activity |
| Biological Process | GO:0051016 | barbed-end actin filament capping |
| Biological Process | GO:0000902 | cell morphogenesis |
| Biological Process | GO:0030030 | cell projection organization |
| Biological Process | GO:0007010 | cytoskeleton organization |
| Biological Process | GO:0030032 | lamellipodium assembly |
| Biological Process | GO:0055001 | muscle cell development |
| Biological Process | GO:0051490 | negative regulation of filopodium assembly |
| Biological Process | GO:0031115 | negative regulation of microtubule polymerization |
| Biological Process | GO:0031175 | neuron projection development |
| Biological Process | GO:0022604 | regulation of cell morphogenesis |
| Biological Process | GO:0010591 | regulation of lamellipodium assembly |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.