Search Results
Overview
| Uniprot ID | P47819 |
|---|---|
| Protein Name | Glial fibrillary acidic protein |
| Gene Name | Gfap |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 109 | LRAKEPTKLADVYQA |
| 152 | DLGTLRQKLQDETNL |
| 200 | EEIQFLRKIHEEEVR |
| 258 | TEEWYRSKFADLTDV |
| 277 | AELLRQAKHEANDYR |
| 337 | EEEGQSLKEEMARHL |
| 366 | IEIATYRKLLEGEEN |
| 395 | RETSLDTKSVSEGHL |
| 403 | SVSEGHLKRNIVVKT |
| 409 | LKRNIVVKTVEMRDG |
| 84 | RFASYIEKVRFLEQQ |
Function
GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells
Protein Sequence
10
MERRRITSAR
20
RSYASSETMV
30
RGHGPTRHLG
40
TIPRLSLSRM
50
TPPLPARVDF
60
SLAGALNAGF
70
KETRASERAE
80
MMELNDRFAS
90
YIEKVRFLEQ
100
QNKALAAELN
110
QLRAKEPTKL
120
ADVYQAELRE
130
LRLRLDQLTT
140
NSARLEVERD
150
NLTQDLGTLR
160
QKLQDETNLR
170
LEAENNLAVY
180
RQEADEATLA
190
RVDLERKVES
200
LEEEIQFLRK
210
IHEEEVRELQ
220
EQLAQQQVHV
230
EMDVAKPDLT
240
AALREIRTQY
250
EAVATSNMQE
260
TEEWYRSKFA
270
DLTDVASRNA
280
ELLRQAKHEA
290
NDYRRQLQAL
300
TCDLESLRGT
310
NESLERQMRE
320
QEERHARESA
330
SYQEALARLE
340
EEGQSLKEEM
350
ARHLQEYQDL
360
LNVKLALDIE
370
IATYRKLLEG
380
EENRITIPVQ
390
TFSNLQIRET
400
SLDTKSVSEG
410
HLKRNIVVKT
420
VEMRDGEVIK
430
ESKQEHKDVM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0097450 | astrocyte end-foot |
| Cellular Component | GO:0097449 | astrocyte projection |
| Cellular Component | GO:0044297 | cell body |
| Cellular Component | GO:0042995 | cell projection |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0098574 | cytoplasmic side of lysosomal membrane |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0097386 | glial cell projection |
| Cellular Component | GO:0005882 | intermediate filament |
| Cellular Component | GO:0045111 | intermediate filament cytoskeleton |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0016020 | membrane |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0005178 | integrin binding |
| Molecular Function | GO:0019900 | kinase binding |
| Molecular Function | GO:0005200 | structural constituent of cytoskeleton |
| Biological Process | GO:0014002 | astrocyte development |
| Biological Process | GO:0060020 | Bergmann glial cell differentiation |
| Biological Process | GO:0070779 | D-aspartate import across plasma membrane |
| Biological Process | GO:0048484 | enteric nervous system development |
| Biological Process | GO:0030198 | extracellular matrix organization |
| Biological Process | GO:0010467 | gene expression |
| Biological Process | GO:0045109 | intermediate filament organization |
| Biological Process | GO:0045103 | intermediate filament-based process |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:0060291 | long-term synaptic potentiation |
| Biological Process | GO:0010977 | negative regulation of neuron projection development |
| Biological Process | GO:0001755 | neural crest cell migration |
| Biological Process | GO:0031102 | neuron projection regeneration |
| Biological Process | GO:0060252 | positive regulation of glial cell proliferation |
| Biological Process | GO:0010625 | positive regulation of Schwann cell proliferation |
| Biological Process | GO:1904714 | regulation of chaperone-mediated autophagy |
| Biological Process | GO:0051580 | regulation of neurotransmitter uptake |
| Biological Process | GO:0045471 | response to ethanol |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.