Search Results
Overview
| Uniprot ID | P47857 |
|---|---|
| Protein Name | ATP-dependent 6-phosphofructokinase, muscle type |
| Gene Name | Pfkm |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 678 | FDRNFATKMGAKAMN |
Function
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
Protein Sequence
10
MTHEEHHAAK
20
TLGIGKAIAV
30
LTSGGDAQGM
40
NAAVRAVVRV
50
GIFTGARVFF
60
VHEGYQGLVD
70
GGEHIREATW
80
ESVSMMLQLG
90
GTVIGSARCK
100
DFREREGRLR
110
AAHNLVKRGI
120
TNLCVIGGDG
130
SLTGADTFRS
140
EWSDLLNDLQ
150
KDGKITAEEA
160
TKSSYLNIVG
170
LVGSIDNDFC
180
GTDMTIGTDS
190
ALHRIVEIVD
200
AITTTAQSHQ
210
RTFVLEVMGR
220
HCGYLALVTS
230
LSCGADWVFI
240
PECPPDDDWE
250
EHLCRRLSET
260
RTRGSRLNII
270
IVAEGAIDKN
280
GKPITSEDIK
290
NLVVKRLGYD
300
TRVTVLGHVQ
310
RGGTPSAFDR
320
ILGSRMGVEA
330
VMALLEGTPD
340
TPACVVSLSG
350
NQAVRLPLME
360
CVQVTKDVTK
370
AMDEKRFDEA
380
IKLRGRSFMN
390
NWEVYKLLAH
400
VRPPVSKGGL
410
HTVAVMNVGA
420
PAAGMNAAVR
430
STVRIGLIQG
440
NRVLVVHDGF
450
EGLAKGQIEE
460
AGWSYVGGWT
470
GQGGSKLGTK
480
RTLPKKNLEQ
490
ISANITKFNI
500
QGLVIIGGFE
510
AYTGGLELME
520
GRKQFDELCI
530
PFVVIPATVS
540
NNVPGSDFSI
550
GADTALNTIC
560
TTCDRIKQSA
570
AGTKRRVFII
580
ETMGGYCGYL
590
ATMAGLAAGA
600
DAAYIFEEPF
610
TIRDLQVNVE
620
HLVQKMKTTV
630
KRGLVLRNEK
640
CNENYTTDFI
650
FNLYSEEGKG
660
IFDSRKNVLG
670
HMQQGGSPTP
680
FDRNFATKMG
690
AKAMNWMSGK
700
IKESYRNGRI
710
FANTPDSGCV
720
LGMRKRALVF
730
QPVTELKDQT
740
DFEHRIPKEQ
750
WWLKLRPILK
760
ILAKYEIDLD
770
TSDHAHLEHI
780
SRKRSGEAAV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005945 | 6-phosphofructokinase complex |
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0097228 | sperm principal piece |
| Molecular Function | GO:0003872 | 6-phosphofructokinase activity |
| Molecular Function | GO:0016208 | AMP binding |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0030246 | carbohydrate binding |
| Molecular Function | GO:0070061 | fructose binding |
| Molecular Function | GO:0070095 | fructose-6-phosphate binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0019900 | kinase binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0008443 | phosphofructokinase activity |
| Biological Process | GO:0061621 | canonical glycolysis |
| Biological Process | GO:0030388 | fructose 1,6-bisphosphate metabolic process |
| Biological Process | GO:0006002 | fructose 6-phosphate metabolic process |
| Biological Process | GO:0042593 | glucose homeostasis |
| Biological Process | GO:0005980 | glycogen catabolic process |
| Biological Process | GO:0093001 | glycolysis from storage polysaccharide through glucose-1-phosphate |
| Biological Process | GO:0006096 | glycolytic process |
| Biological Process | GO:0061615 | glycolytic process through fructose-6-phosphate |
| Biological Process | GO:0046716 | muscle cell cellular homeostasis |
| Biological Process | GO:0032024 | positive regulation of insulin secretion |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.
[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.