Overview
| Uniprot ID | P47863 |
|---|
| Protein Name | Aquaporin-4 |
|---|
| Gene Name | Aqp4 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 268 |
RLKEAFSKAAQQTKG |
| 274 |
SKAAQQTKGSYMEVE |
| 311 |
IDRGDEKKGKDSSGE |
| 313 |
RGDEKKGKDSSGEVL |
Function
Forms a water-specific channel (PubMed:19800950, PubMed:7509789, PubMed:7528931). Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability (By similarity)
Protein Sequence
10
MSDGAAARRW
20
GKCGPPCSRE
30
SIMVAFKGVW
40
TQAFWKAVTA
50
EFLAMLIFVL
60
LSVGSTINWG
70
GSENPLPVDM
80
VLISLCFGLS
90
IATMVQCFGH
100
ISGGHINPAV
110
TVAMVCTRKI
120
SIAKSVFYIT
130
AQCLGAIIGA
140
GILYLVTPPS
150
VVGGLGVTTV
160
HGNLTAGHGL
170
LVELIITFQL
180
VFTIFASCDS
190
KRTDVTGSVA
200
LAIGFSVAIG
210
HLFAINYTGA
220
SMNPARSFGP
230
AVIMGNWENH
240
WIYWVGPIIG
250
AVLAGALYEY
260
VFCPDVELKR
270
RLKEAFSKAA
280
QQTKGSYMEV
290
EDNRSQVETE
300
DLILKPGVVH
310
VIDIDRGDEK
320
KGKDSSGEVL
SSV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0097450 |
astrocyte end-foot |
| Biological Process |
GO:0071347 |
cellular response to interleukin-1 |
| Biological Process |
GO:0071354 |
cellular response to interleukin-6 |
| Biological Process |
GO:0071346 |
cellular response to type II interferon |
| Biological Process |
GO:0090660 |
cerebrospinal fluid circulation |
| Biological Process |
GO:0033326 |
cerebrospinal fluid secretion |
| Biological Process |
GO:0007565 |
female pregnancy |
| Biological Process |
GO:0009992 |
intracellular water homeostasis |
| Biological Process |
GO:0050891 |
multicellular organismal-level water homeostasis |
| Biological Process |
GO:0060354 |
negative regulation of cell adhesion molecule production |
| Biological Process |
GO:0032691 |
negative regulation of interleukin-1 beta production |
| Biological Process |
GO:0032715 |
negative regulation of interleukin-6 production |
| Biological Process |
GO:0051289 |
protein homotetramerization |
| Biological Process |
GO:0010574 |
regulation of vascular endothelial growth factor production |
| Biological Process |
GO:0070295 |
renal water absorption |
| Biological Process |
GO:0045471 |
response to ethanol |
| Biological Process |
GO:0051384 |
response to glucocorticoid |
| Biological Process |
GO:0007605 |
sensory perception of sound |
| Biological Process |
GO:0006833 |
water transport |
| Cellular Component |
GO:0009925 |
basal plasma membrane |
| Cellular Component |
GO:0016323 |
basolateral plasma membrane |
| Cellular Component |
GO:0030054 |
cell junction |
| Cellular Component |
GO:0031253 |
cell projection membrane |
| Cellular Component |
GO:0005911 |
cell-cell junction |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0010008 |
endosome membrane |
| Cellular Component |
GO:0009897 |
external side of plasma membrane |
| Cellular Component |
GO:0005576 |
extracellular region |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0032991 |
protein-containing complex |
| Cellular Component |
GO:0042383 |
sarcolemma |
| Cellular Component |
GO:0030315 |
T-tubule |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0015250 |
water channel activity |
| Biological Process |
GO:0015670 |
carbon dioxide transport |
| Biological Process |
GO:0098609 |
cell-cell adhesion |
| Biological Process |
GO:0071392 |
cellular response to estradiol stimulus |
| Biological Process |
GO:0071333 |
cellular response to glucose stimulus |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.