Search Results
Overview
| Uniprot ID | P47897 |
|---|---|
| Protein Name | Glutamine--tRNA ligase |
| Gene Name | QARS1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 496 | LHYAVVSKRKILQLV |
| 80 | VSYIASKKIHTEPQL |
Function
Glutamine--tRNA ligase (PubMed:26869582). Plays a critical role in brain development (PubMed:24656866)
Protein Sequence
10
MAALDSLSLF
20
TSLGLSEQKA
30
RETLKNSALS
40
AQLREAATQA
50
QQTLGSTIDK
60
ATGILLYGLA
70
SRLRDTRRLS
80
FLVSYIASKK
90
IHTEPQLSAA
100
LEYVRSHPLD
110
PIDTVDFERE
120
CGVGVIVTPE
130
QIEEAVEAAI
140
NRHRPQLLVE
150
RYHFNMGLLM
160
GEARAVLKWA
170
DGKMIKNEVD
180
MQVLHLLGPK
190
LEADLEKKFK
200
VAKARLEETD
210
RRTAKDVVEN
220
GETADQTLSL
230
MEQLRGEALK
240
FHKPGENYKT
250
PGYVVTPHTM
260
NLLKQHLEIT
270
GGQVRTRFPP
280
EPNGILHIGH
290
AKAINFNFGY
300
AKANNGICFL
310
RFDDTNPEKE
320
EAKFFTAICD
330
MVAWLGYTPY
340
KVTYASDYFD
350
QLYAWAVELI
360
RRGLAYVCHQ
370
RGEELKGHNT
380
LPSPWRDRPM
390
EESLLLFEAM
400
RKGKFSEGEA
410
TLRMKLVMED
420
GKMDPVAYRV
430
KYTPHHRTGD
440
KWCIYPTYDY
450
THCLCDSIEH
460
ITHSLCTKEF
470
QARRSSYFWL
480
CNALDVYCPV
490
QWEYGRLNLH
500
YAVVSKRKIL
510
QLVATGAVRD
520
WDDPRLFTLT
530
ALRRRGFPPE
540
AINNFCARVG
550
VTVAQTTMEP
560
HLLEACVRDV
570
LNDTAPRAMA
580
VLESLRVIIT
590
NFPAAKSLDI
600
QVPNFPADET
610
KGFHQVPFAP
620
IVFIERTDFK
630
EEPEPGFKRL
640
AWGQPVGLRH
650
TGYVIELQHV
660
VKGPSGCVES
670
LEVTCRRADA
680
GEKPKAFIHW
690
VSQPLMCEVR
700
LYERLFQHKN
710
PEDPTEVPGG
720
FLSDLNLASL
730
HVVDAALVDC
740
SVALAKPFDK
750
FQFERLGYFS
760
VDPDSHQGKL
770
VFNRTVTLKE
DPGKV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004819 | glutamine-tRNA ligase activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0004860 | protein kinase inhibitor activity |
| Biological Process | GO:0007420 | brain development |
| Biological Process | GO:0006425 | glutaminyl-tRNA aminoacylation |
| Biological Process | GO:2001234 | negative regulation of apoptotic signaling pathway |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0032873 | negative regulation of stress-activated MAPK cascade |
| Biological Process | GO:0006418 | tRNA aminoacylation for protein translation |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.