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Overview

Uniprot IDP47934
Protein NameCarnitine O-acetyltransferase
Gene NameCrat
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
195 DSVVNFLKSKRPPTH
245 NSSLQSNKEPVGILT
261 NHRNTWAKAYNNLIK
268 KAYNNLIKDKVNRES
390 FNITPEIKNDIEKAK
609 RMAHYLEKALLDMRT
85 GVGERLQKGLERRAK

Function

Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta-oxidation. Responsible for the synthesis of short- and branched-chain acylcarnitines. Active towards some branched-chain amino acid oxidation pathway (BCAAO) intermediates. Trans-2-enoyl-CoAs and 2-methylacyl-CoAs are poor substrates

Protein Sequence

10 MLAFAARTVV 20 KPLGLLKPSS 30 LMKVSGRFKA 40 HQDALPRLPV 50 PPLQQSLDYY 60 LKALQPIVSE 70 EEWAHTKQLV 80 DEFQTSGGVG 90 ERLQKGLERR 100 AKKMENWLSE 110 WWLKTAYLQF 120 RQPVVIYSSP 130 GVILPKQDFV 140 DLQGQLRFAA 150 KLIEGVLDFK 160 SMIDNETLPV 170 EFLGGQPLCM 180 NQYYQILSSC 190 RVPGPKQDSV 200 VNFLKSKRPP 210 THITVVHNYQ 220 FFELDVYHSD 230 GTPLTSDQIF 240 VQLEKIWNSS 250 LQSNKEPVGI 260 LTSNHRNTWA 270 KAYNNLIKDK 280 VNRESVNSIQ 290 KSIFTVCLDK 300 QVPRVSDDVY 310 RNHVAGQMLH 320 GGGSKFNSGN 330 RWFDKTLQFI 340 VAEDGSCGMV 350 YEHAAAEGPP 360 IVALVDHVME 370 YTKKPELVRS 380 PMVPLPMPKK 390 LRFNITPEIK 400 NDIEKAKQNL 410 SIMIQDLDIM 420 MLTFHHFGKD 430 FPKSEKLSPD 440 AFIQVALQLA 450 YYRIYGQACA 460 TYESASLRMF 470 HLGRTDTIRS 480 ASIDSLAFVK 490 GMGDSTVPEQ 500 QKVELLRKAV 510 QAHRAYTDRA 520 IRGEAFDRHL 530 LGLKLQAIED 540 LVSMPDIFMD 550 TSYAIAMHFN 560 LSTSQVPAKT 570 DCVMFFGPVV 580 PDGYGICYNP 590 MEAHINFSVS 600 AYNSCAETNA 610 ARMAHYLEKA 620 LLDMRTLLQN HPRAKL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005777 peroxisome
Molecular Function GO:0003997 acyl-CoA oxidase activity
Molecular Function GO:0004092 carnitine O-acetyltransferase activity
Molecular Function GO:0008458 carnitine O-octanoyltransferase activity
Biological Process GO:0019254 carnitine metabolic process, CoA-linked
Biological Process GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase
Biological Process GO:0006631 fatty acid metabolic process
Biological Process GO:0051791 medium-chain fatty acid metabolic process
Biological Process GO:0046459 short-chain fatty acid metabolic process
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005739 mitochondrion

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.