Search Results
Overview
| Uniprot ID | P47942 |
|---|---|
| Protein Name | Dihydropyrimidinase-related protein 2 |
| Gene Name | Dpysl2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 258 | YVTKVMSKSAAEVIA |
| 472 | SGRYIPRKPFPDFVY |
| 520 | VTPASSAKTSPAKQQ |
| 525 | SAKTSPAKQQAPPVR |
Function
Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis (By similarity)
Protein Sequence
10
MSYQGKKNIP
20
RITSDRLLIK
30
GGKIVNDDQS
40
FYADIYMEDG
50
LIKQIGENLI
60
VPGGVKTIEA
70
HSRMVIPGGI
80
DVHTRFQMPD
90
QGMTSADDFF
100
QGTKAALAGG
110
TTMIIDHVVP
120
EPGTSLLAAF
130
DQWREWADSK
140
SCCDYSLHVD
150
ITEWHKGIQE
160
EMEALVKDHG
170
VNSFLVYMAF
180
KDRFQLTDSQ
190
IYEVLSVIRD
200
IGAIAQVHAE
210
NGDIIAEEQQ
220
RILDLGITGP
230
EGHVLSRPEE
240
VEAEAVNRSI
250
TIANQTNCPL
260
YVTKVMSKSA
270
AEVIAQARKK
280
GTVVYGEPIT
290
ASLGTDGSHY
300
WSKNWAKAAA
310
FVTSPPLSPD
320
PTTPDFLNSL
330
LSCGDLQVTG
340
SAHCTFNTAQ
350
KAVGKDNFTL
360
IPEGTNGTEE
370
RMSVIWDKAV
380
VTGKMDENQF
390
VAVTSTNAAK
400
VFNLYPRKGR
410
ISVGSDADLV
420
IWDPDSVKTI
430
SAKTHNSALE
440
YNIFEGMECR
450
GSPLVVISQG
460
KIVLEDGTLH
470
VTEGSGRYIP
480
RKPFPDFVYK
490
RIKARSRLAE
500
LRGVPRGLYD
510
GPVCEVSVTP
520
KTVTPASSAK
530
TSPAKQQAPP
540
VRNLHQSGFS
550
LSGAQIDDNI
560
PRRTTQRIVA
570
PPGGRANITS
LG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0015630 | microtubule cytoskeleton |
| Cellular Component | GO:0043209 | myelin sheath |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0043195 | terminal bouton |
| Molecular Function | GO:0016812 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0007010 | cytoskeleton organization |
| Biological Process | GO:0006897 | endocytosis |
| Biological Process | GO:0021772 | olfactory bulb development |
| Biological Process | GO:0014049 | positive regulation of glutamate secretion |
| Biological Process | GO:0030516 | regulation of axon extension |
| Biological Process | GO:0045664 | regulation of neuron differentiation |
| Biological Process | GO:0010975 | regulation of neuron projection development |
| Biological Process | GO:0150052 | regulation of postsynapse assembly |
| Biological Process | GO:0001975 | response to amphetamine |
| Biological Process | GO:0042220 | response to cocaine |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0021510 | spinal cord development |
| Biological Process | GO:0048489 | synaptic vesicle transport |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.