Search Results

Overview

Uniprot IDP47989
Protein NameXanthine dehydrogenase/oxidase
Gene NameXDH
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
249 LKELLDLKAQHPDAK
323 VAKLPAQKTEVFRGV
468 NRTISALKTTQRQLS
5 ***MTADKLVFFVNG
660 ETVFAKDKVTCVGHI
949 VRRKNLYKEGDLTHF

Function

Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro)

Protein Sequence

10 MTADKLVFFV 20 NGRKVVEKNA 30 DPETTLLAYL 40 RRKLGLSGTK 50 LGCGEGGCGA 60 CTVMLSKYDR 70 LQNKIVHFSA 80 NACLAPICSL 90 HHVAVTTVEG 100 IGSTKTRLHP 110 VQERIAKSHG 120 SQCGFCTPGI 130 VMSMYTLLRN 140 QPEPTMEEIE 150 NAFQGNLCRC 160 TGYRPILQGF 170 RTFARDGGCC 180 GGDGNNPNCC 190 MNQKKDHSVS 200 LSPSLFKPEE 210 FTPLDPTQEP 220 IFPPELLRLK 230 DTPRKQLRFE 240 GERVTWIQAS 250 TLKELLDLKA 260 QHPDAKLVVG 270 NTEIGIEMKF 280 KNMLFPMIVC 290 PAWIPELNSV 300 EHGPDGISFG 310 AACPLSIVEK 320 TLVDAVAKLP 330 AQKTEVFRGV 340 LEQLRWFAGK 350 QVKSVASVGG 360 NIITASPISD 370 LNPVFMASGA 380 KLTLVSRGTR 390 RTVQMDHTFF 400 PGYRKTLLSP 410 EEILLSIEIP 420 YSREGEYFSA 430 FKQASRREDD 440 IAKVTSGMRV 450 LFKPGTTEVQ 460 ELALCYGGMA 470 NRTISALKTT 480 QRQLSKLWKE 490 ELLQDVCAGL 500 AEELHLPPDA 510 PGGMVDFRCT 520 LTLSFFFKFY 530 LTVLQKLGQE 540 NLEDKCGKLD 550 PTFASATLLF 560 QKDPPADVQL 570 FQEVPKGQSE 580 EDMVGRPLPH 590 LAADMQASGE 600 AVYCDDIPRY 610 ENELSLRLVT 620 STRAHAKIKS 630 IDTSEAKKVP 640 GFVCFISADD 650 VPGSNITGIC 660 NDETVFAKDK 670 VTCVGHIIGA 680 VVADTPEHTQ 690 RAAQGVKITY 700 EELPAIITIE 710 DAIKNNSFYG 720 PELKIEKGDL 730 KKGFSEADNV 740 VSGEIYIGGQ 750 EHFYLETHCT 760 IAVPKGEAGE 770 MELFVSTQNT 780 MKTQSFVAKM 790 LGVPANRIVV 800 RVKRMGGGFG 810 GKETRSTVVS 820 TAVALAAYKT 830 GRPVRCMLDR 840 DEDMLITGGR 850 HPFLARYKVG 860 FMKTGTVVAL 870 EVDHFSNVGN 880 TQDLSQSIME 890 RALFHMDNCY 900 KIPNIRGTGR 910 LCKTNLPSNT 920 AFRGFGGPQG 930 MLIAECWMSE 940 VAVTCGMPAE 950 EVRRKNLYKE 960 GDLTHFNQKL 970 EGFTLPRCWE 980 ECLASSQYHA 990 RKSEVDKFNK 1000 ENCWKKRGLC 1010 IIPTKFGISF 1020 TVPFLNQAGA 1030 LLHVYTDGSV 1040 LLTHGGTEMG 1050 QGLHTKMVQV 1060 ASRALKIPTS 1070 KIYISETSTN 1080 TVPNTSPTAA 1090 SVSADLNGQA 1100 VYAACQTILK 1110 RLEPYKKKNP 1120 SGSWEDWVTA 1130 AYMDTVSLSA 1140 TGFYRTPNLG 1150 YSFETNSGNP 1160 FHYFSYGVAC 1170 SEVEIDCLTG 1180 DHKNLRTDIV 1190 MDVGSSLNPA 1200 IDIGQVEGAF 1210 VQGLGLFTLE 1220 ELHYSPEGSL 1230 HTRGPSTYKI 1240 PAFGSIPIEF 1250 RVSLLRDCPN 1260 KKAIYASKAV 1270 GEPPLFLAAS 1280 IFFAIKDAIR 1290 AARAQHTGNN 1300 VKELFRLDSP 1310 ATPEKIRNAC 1320 VDKFTTLCVT 1330 GVPENCKPWS VRV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Biological Process GO:0006157 deoxyadenosine catabolic process
Biological Process GO:0006161 deoxyguanosine catabolic process
Biological Process GO:0006149 deoxyinosine catabolic process
Biological Process GO:0046055 dGMP catabolic process
Biological Process GO:0046038 GMP catabolic process
Biological Process GO:0006147 guanine catabolic process
Biological Process GO:0009114 hypoxanthine catabolic process
Biological Process GO:0006204 IMP catabolic process
Biological Process GO:0006148 inosine catabolic process
Biological Process GO:0009115 xanthine catabolic process
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005777 peroxisome
Cellular Component GO:0016529 sarcoplasmic reticulum
Molecular Function GO:0051537 2 iron, 2 sulfur cluster binding
Molecular Function GO:0071949 FAD binding
Molecular Function GO:0050660 flavin adenine dinucleotide binding
Molecular Function GO:0070674 hypoxanthine dehydrogenase activity
Molecular Function GO:0070675 hypoxanthine oxidase activity
Molecular Function GO:0005506 iron ion binding
Molecular Function GO:0043546 molybdopterin cofactor binding
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0004854 xanthine dehydrogenase activity
Molecular Function GO:0004855 xanthine oxidase activity
Biological Process GO:0006154 adenosine catabolic process
Biological Process GO:0000255 allantoin metabolic process
Biological Process GO:0006196 AMP catabolic process
Biological Process GO:0046059 dAMP catabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.