Overview
| Uniprot ID | P48004 |
|---|
| Protein Name | Proteasome subunit alpha type-7 |
|---|
| Gene Name | Psma7 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 52 |
VEKKSVAKLQDERTV |
Function
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response
Protein Sequence
10
MSYDRAITVF
20
SPDGHLFQVE
30
YAQEAVKKGS
40
TAVGVRGRDI
50
VVLGVEKKSV
60
AKLQDERTVR
70
KICALDDNVC
80
MAFAVVASVS
90
GLTADARIVI
100
NRARVECQSH
110
RLTVGDPVTV
120
EYITRYIASL
130
KQRYTQSNGR
140
RPFGISALIV
150
GFDFDGTPRL
160
YQTDPSGTYH
170
AWKANAIGRG
180
AKSVREFLEK
190
NYTDDAIETD
200
DLTIKLVIKA
210
LLEVVQSGGK
220
NIELAVMRRD
230
QPLKILSPEE
240
IEKYVAEIEK
250
EKEENEKKKQ
KKAS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0000502 |
proteasome complex |
| Cellular Component |
GO:0005839 |
proteasome core complex |
| Cellular Component |
GO:0019773 |
proteasome core complex, alpha-subunit complex |
| Cellular Component |
GO:0008021 |
synaptic vesicle |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Biological Process |
GO:0010498 |
proteasomal protein catabolic process |
| Biological Process |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process |
GO:0061136 |
regulation of proteasomal protein catabolic process |
| Biological Process |
GO:0006979 |
response to oxidative stress |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.