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Overview

Uniprot IDP48058
Protein NameGlutamate receptor 4
Gene NameGRIA4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
783 SEAGVLDKLKNKWWY

Function

Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (By similarity). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission (By similarity). Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (By similarity). In the presence of CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate (PubMed:21172611)

Protein Sequence

10 MRIISRQIVL 20 LFSGFWGLAM 30 GAFPSSVQIG 40 GLFIRNTDQE 50 YTAFRLAIFL 60 HNTSPNASEA 70 PFNLVPHVDN 80 IETANSFAVT 90 NAFCSQYSRG 100 VFAIFGLYDK 110 RSVHTLTSFC 120 SALHISLITP 130 SFPTEGESQF 140 VLQLRPSLRG 150 ALLSLLDHYE 160 WNCFVFLYDT 170 DRGYSILQAI 180 MEKAGQNGWH 190 VSAICVENFN 200 DVSYRQLLEE 210 LDRRQEKKFV 220 IDCEIERLQN 230 ILEQIVSVGK 240 HVKGYHYIIA 250 NLGFKDISLE 260 RFIHGGANVT 270 GFQLVDFNTP 280 MVIKLMDRWK 290 KLDQREYPGS 300 ETPPKYTSAL 310 TYDGVLVMAE 320 TFRSLRRQKI 330 DISRRGNAGD 340 CLANPAAPWG 350 QGIDMERTLK 360 QVRIQGLTGN 370 VQFDHYGRRV 380 NYTMDVFELK 390 STGPRKVGYW 400 NDMDKLVLIQ 410 DVPTLGNDTA 420 AIENRTVVVT 430 TIMESPYVMY 440 KKNHEMFEGN 450 DKYEGYCVDL 460 ASEIAKHIGI 470 KYKIAIVPDG 480 KYGARDADTK 490 IWNGMVGELV 500 YGKAEIAIAP 510 LTITLVREEV 520 IDFSKPFMSL 530 GISIMIKKPQ 540 KSKPGVFSFL 550 DPLAYEIWMC 560 IVFAYIGVSV 570 VLFLVSRFSP 580 YEWHTEEPED 590 GKEGPSDQPP 600 NEFGIFNSLW 610 FSLGAFMQQG 620 CDISPRSLSG 630 RIVGGVWWFF 640 TLIIISSYTA 650 NLAAFLTVER 660 MVSPIESAED 670 LAKQTEIAYG 680 TLDSGSTKEF 690 FRRSKIAVYE 700 KMWTYMRSAE 710 PSVFTRTTAE 720 GVARVRKSKG 730 KFAFLLESTM 740 NEYIEQRKPC 750 DTMKVGGNLD 760 SKGYGVATPK 770 GSSLRTPVNL 780 AVLKLSEAGV 790 LDKLKNKWWY 800 DKGECGPKDS 810 GSKDKTSALS 820 LSNVAGVFYI 830 LVGGLGLAML 840 VALIEFCYKS 850 RAEAKRMKLT 860 FSEAIRNKAR 870 LSITGSVGEN 880 GRVLTPDCPK 890 AVHTGTAIRQ 900 SSGLAVIASD LP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0032281 AMPA glutamate receptor complex
Cellular Component GO:0030425 dendrite
Cellular Component GO:0043197 dendritic spine
Cellular Component GO:0030666 endocytic vesicle membrane
Cellular Component GO:1903561 extracellular vesicle
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0098839 postsynaptic density membrane
Molecular Function GO:0004971 AMPA glutamate receptor activity
Molecular Function GO:0001540 amyloid-beta binding
Molecular Function GO:0004970 glutamate-gated receptor activity
Molecular Function GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
Molecular Function GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Biological Process GO:0007215 glutamate receptor signaling pathway
Biological Process GO:0050804 modulation of chemical synaptic transmission
Biological Process GO:0034392 negative regulation of smooth muscle cell apoptotic process
Biological Process GO:0035249 synaptic transmission, glutamatergic

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.