Search Results
Overview
| Uniprot ID | P48163 |
|---|---|
| Protein Name | NADP-dependent malic enzyme |
| Gene Name | ME1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 342 | DSKGLIVKGRASLTQ |
| 351 | RASLTQEKEKFAHEH |
| 422 | CSAEQCYKITKGRAI |
| 525 | VKDAYQEKTATVYPE |
Function
Catalyzes the oxidative decarboxylation of (S)-malate in the presence of NADP(+) and divalent metal ions, and decarboxylation of oxaloacetate
Protein Sequence
10
MEPEAPRRRH
20
THQRGYLLTR
30
NPHLNKDLAF
40
TLEERQQLNI
50
HGLLPPSFNS
60
QEIQVLRVVK
70
NFEHLNSDFD
80
RYLLLMDLQD
90
RNEKLFYRVL
100
TSDIEKFMPI
110
VYTPTVGLAC
120
QQYSLVFRKP
130
RGLFITIHDR
140
GHIASVLNAW
150
PEDVIKAIVV
160
TDGERILGLG
170
DLGCNGMGIP
180
VGKLALYTAC
190
GGMNPQECLP
200
VILDVGTENE
210
ELLKDPLYIG
220
LRQRRVRGSE
230
YDDFLDEFME
240
AVSSKYGMNC
250
LIQFEDFANV
260
NAFRLLNKYR
270
NQYCTFNDDI
280
QGTASVAVAG
290
LLAALRITKN
300
KLSDQTILFQ
310
GAGEAALGIA
320
HLIVMALEKE
330
GLPKEKAIKK
340
IWLVDSKGLI
350
VKGRASLTQE
360
KEKFAHEHEE
370
MKNLEAIVQE
380
IKPTALIGVA
390
AIGGAFSEQI
400
LKDMAAFNER
410
PIIFALSNPT
420
SKAECSAEQC
430
YKITKGRAIF
440
ASGSPFDPVT
450
LPNGQTLYPG
460
QGNNSYVFPG
470
VALGVVACGL
480
RQITDNIFLT
490
TAEVIAQQVS
500
DKHLEEGRLY
510
PPLNTIRDVS
520
LKIAEKIVKD
530
AYQEKTATVY
540
PEPQNKEAFV
550
RSQMYSTDYD
560
QILPDCYSWP
570
EEVQKIQTKV
DQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0043531 | ADP binding |
| Molecular Function | GO:0009055 | electron transfer activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0004473 | malate dehydrogenase (decarboxylating) (NADP+) activity |
| Molecular Function | GO:0004470 | malic enzyme activity |
| Molecular Function | GO:0030145 | manganese ion binding |
| Molecular Function | GO:0051287 | NAD binding |
| Molecular Function | GO:0050661 | NADP binding |
| Molecular Function | GO:0008948 | oxaloacetate decarboxylase activity |
| Biological Process | GO:0005975 | carbohydrate metabolic process |
| Biological Process | GO:0006108 | malate metabolic process |
| Biological Process | GO:0019674 | NAD+ metabolic process |
| Biological Process | GO:0006739 | NADP+ metabolic process |
| Biological Process | GO:0009165 | nucleotide biosynthetic process |
| Biological Process | GO:0051289 | protein homotetramerization |
| Biological Process | GO:1902031 | regulation of NADP metabolic process |
| Biological Process | GO:0009743 | response to carbohydrate |
| Biological Process | GO:0009725 | response to hormone |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.