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Overview

Uniprot IDP48449
Protein NameLanosterol synthase
Gene NameLSS
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
318 LRQRAVQKLYEHIVA

Function

Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus (PubMed:14766201, PubMed:26200341, PubMed:7639730). Through the production of lanosterol may regulate lens protein aggregation and increase transparency (PubMed:26200341)

Protein Sequence

10 MTEGTCLRRR 20 GGPYKTEPAT 30 DLGRWRLNCE 40 RGRQTWTYLQ 50 DERAGREQTG 60 LEAYALGLDT 70 KNYFKDLPKA 80 HTAFEGALNG 90 MTFYVGLQAE 100 DGHWTGDYGG 110 PLFLLPGLLI 120 TCHVARIPLP 130 AGYREEIVRY 140 LRSVQLPDGG 150 WGLHIEDKST 160 VFGTALNYVS 170 LRILGVGPDD 180 PDLVRARNIL 190 HKKGGAVAIP 200 SWGKFWLAVL 210 NVYSWEGLNT 220 LFPEMWLFPD 230 WAPAHPSTLW 240 CHCRQVYLPM 250 SYCYAVRLSA 260 AEDPLVQSLR 270 QELYVEDFAS 280 IDWLAQRNNV 290 APDELYTPHS 300 WLLRVVYALL 310 NLYEHHHSAH 320 LRQRAVQKLY 330 EHIVADDRFT 340 KSISIGPISK 350 TINMLVRWYV 360 DGPASTAFQE 370 HVSRIPDYLW 380 MGLDGMKMQG 390 TNGSQIWDTA 400 FAIQALLEAG 410 GHHRPEFSSC 420 LQKAHEFLRL 430 SQVPDNPPDY 440 QKYYRQMRKG 450 GFSFSTLDCG 460 WIVSDCTAEA 470 LKAVLLLQEK 480 CPHVTEHIPR 490 ERLCDAVAVL 500 LNMRNPDGGF 510 ATYETKRGGH 520 LLELLNPSEV 530 FGDIMIDYTY 540 VECTSAVMQA 550 LKYFHKRFPE 560 HRAAEIRETL 570 TQGLEFCRRQ 580 QRADGSWEGS 590 WGVCFTYGTW 600 FGLEAFACMG 610 QTYRDGTACA 620 EVSRACDFLL 630 SRQMADGGWG 640 EDFESCEERR 650 YLQSAQSQIH 660 NTCWAMMGLM 670 AVRHPDIEAQ 680 ERGVRCLLEK 690 QLPNGDWPQE 700 NIAGVFNKSC 710 AISYTSYRNI 720 FPIWALGRFS 730 QLYPERALAG HP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0098554 cytoplasmic side of endoplasmic reticulum membrane
Biological Process GO:0036197 zymosterol biosynthetic process
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0005811 lipid droplet
Cellular Component GO:0016020 membrane
Molecular Function GO:0000250 lanosterol synthase activity
Biological Process GO:0006695 cholesterol biosynthetic process
Biological Process GO:0033489 cholesterol biosynthetic process via desmosterol
Biological Process GO:0033490 cholesterol biosynthetic process via lathosterol
Biological Process GO:0031647 regulation of protein stability
Biological Process GO:0006694 steroid biosynthetic process
Biological Process GO:0016104 triterpenoid biosynthetic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.