Search Results
Overview
| Uniprot ID | P48508 |
|---|---|
| Protein Name | Glutamate--cysteine ligase regulatory subunit |
| Gene Name | Gclm |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 34 | NWGRLRKKCPSTHSE |
Function
No function data available.
Protein Sequence
10
MGTDSRAAGA
20
LLARASTLHL
30
QTGNLLNWGR
40
LRKKCPSTHS
50
EELRDCIQKT
60
LNEWSSQISP
70
DLVREFPDVL
80
ECTMSHAVEK
90
INPDEREEMK
100
VSAKLFIVGS
110
NSSSSTRNAV
120
DMACSVLGVA
130
QLDSVIMASP
140
PIEDGVNLSL
150
EHLQPYWEEL
160
ENLVQSKKIV
170
AIGTSDLDKT
180
QLEQLYQWAQ
190
VKPNSNQVNL
200
ASCCVMPPDL
210
TAFAKQFDIQ
220
LLTHNDPKEL
230
LSEASFQEAL
240
QESIPDIEAQ
250
EWVPLWLLRY
260
SVIVKSRGII
270
KSKGYILQAK
RKGS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0017109 | glutamate-cysteine ligase complex |
| Molecular Function | GO:0004357 | glutamate-cysteine ligase activity |
| Molecular Function | GO:0035226 | glutamate-cysteine ligase catalytic subunit binding |
| Molecular Function | GO:1990609 | glutamate-cysteine ligase regulator activity |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Biological Process | GO:0008637 | apoptotic mitochondrial changes |
| Biological Process | GO:0097746 | blood vessel diameter maintenance |
| Biological Process | GO:0044344 | cellular response to fibroblast growth factor stimulus |
| Biological Process | GO:0071372 | cellular response to follicle-stimulating hormone stimulus |
| Biological Process | GO:0071333 | cellular response to glucose stimulus |
| Biological Process | GO:0035729 | cellular response to hepatocyte growth factor stimulus |
| Biological Process | GO:1990830 | cellular response to leukemia inhibitory factor |
| Biological Process | GO:0097069 | cellular response to thyroxine stimulus |
| Biological Process | GO:0006534 | cysteine metabolic process |
| Biological Process | GO:0006536 | glutamate metabolic process |
| Biological Process | GO:0006750 | glutathione biosynthetic process |
| Biological Process | GO:0006749 | glutathione metabolic process |
| Biological Process | GO:0035733 | hepatic stellate cell activation |
| Biological Process | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
| Biological Process | GO:0043524 | negative regulation of neuron apoptotic process |
| Biological Process | GO:0051900 | regulation of mitochondrial depolarization |
| Biological Process | GO:0014823 | response to activity |
| Biological Process | GO:0044752 | response to human chorionic gonadotropin |
| Biological Process | GO:0051409 | response to nitrosative stress |
| Biological Process | GO:0007584 | response to nutrient |
| Biological Process | GO:0006979 | response to oxidative stress |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.