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Overview

Uniprot IDP48556
Protein Name26S proteasome non-ATPase regulatory subunit 8
Gene NamePSMD8
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
105 LKGEWNRKSPNLSKC
138 TTGTKLTKQQLILAR
159 AQWSILRKDIPSFER
297 ILFFNTPKKMTDYAK
298 LFFNTPKKMTDYAKK

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair

Protein Sequence

10 MFIKGRAPRA 20 PPRERRRATR 30 GGLRQVVAPP 40 RALGSTSRPH 50 FRRASVCRRR 60 CRKSGGLLAA 70 SRKMAAAAVN 80 GAAGFSSSGP 90 AATSGAVLQA 100 ATGMYEQLKG 110 EWNRKSPNLS 120 KCGEELGRLK 130 LVLLELNFLP 140 TTGTKLTKQQ 150 LILARDILEI 160 GAQWSILRKD 170 IPSFERYMAQ 180 LKCYYFDYKE 190 QLPESAYMHQ 200 LLGLNLLFLL 210 SQNRVAEFHT 220 ELERLPAKDI 230 QTNVYIKHPV 240 SLEQYLMEGS 250 YNKVFLAKGN 260 IPAESYTFFI 270 DILLDTIRDE 280 IAGCIEKAYE 290 KILFTEATRI 300 LFFNTPKKMT 310 DYAKKRGWVL 320 GPNNYYSFAS 330 QQQKPEDTTI 340 PSTELAKQVI 350 EYARQLEMIV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0022624 proteasome accessory complex
Cellular Component GO:0000502 proteasome complex
Cellular Component GO:0005838 proteasome regulatory particle
Cellular Component GO:0008541 proteasome regulatory particle, lid subcomplex
Cellular Component GO:0008021 synaptic vesicle
Biological Process GO:0071357 cellular response to type I interferon
Biological Process GO:0010498 proteasomal protein catabolic process
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0061136 regulation of proteasomal protein catabolic process
Biological Process GO:0006979 response to oxidative stress

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.