Search Results

Overview

Uniprot IDP48634
Protein NameProtein PRRC2A
Gene NamePRRC2A
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1261 PPRFRRLKQERENAA
1404 RRPGPGGKAGSSGSS
2091 SGLNSRLKATPSTYS
27 LNLFDTYKGKSLEIQ
308 VGRPSILKEDNLKEF
454 EAWRQRRKQSSSEIS
49 HGLQSLGKVAIARRM
638 SQGLGYPKYQKSLPP
641 LGYPKYQKSLPPRFQ
901 TGPEAGRKPARGVGS
995 KGKLGGPKETPPNGN

Function

May play a role in the regulation of pre-mRNA splicing

Protein Sequence

10 MSDRSGPTAK 20 GKDGKKYSSL 30 NLFDTYKGKS 40 LEIQKPAVAP 50 RHGLQSLGKV 60 AIARRMPPPA 70 NLPSLKAENK 80 GNDPNVSLVP 90 KDGTGWASKQ 100 EQSDPKSSDA 110 STAQPPESQP 120 LPASQTPASN 130 QPKRPPAAPE 140 NTPLVPSGVK 150 SWAQASVTHG 160 AHGDGGRASS 170 LLSRFSREEF 180 PTLQAAGDQD 190 KAAKERESAE 200 QSSGPGPSLR 210 PQNSTTWRDG 220 GGRGPDELEG 230 PDSKLHHGHD 240 PRGGLQPSGP 250 PQFPPYRGMM 260 PPFMYPPYLP 270 FPPPYGPQGP 280 YRYPTPDGPS 290 RFPRVAGPRG 300 SGPPMRLVEP 310 VGRPSILKED 320 NLKEFDQLDQ 330 ENDDGWAGAH 340 EEVDYTEKLK 350 FSDEEDGRDS 360 DEEGAEGHRD 370 SQSASGEERP 380 PEADGKKGNS 390 PNSEPPTPKT 400 AWAETSRPPE 410 TEPGPPAPKP 420 PLPPPHRGPA 430 GNWGPPGDYP 440 DRGGPPCKPP 450 APEDEDEAWR 460 QRRKQSSSEI 470 SLAVERARRR 480 REEEERRMQE 490 ERRAACAEKL 500 KRLDEKFGAP 510 DKRLKAEPAA 520 PPAAPSTPAP 530 PPAVPKELPA 540 PPAPPPASAP 550 TPETEPEEPA 560 QAPPAQSTPT 570 PGVAAAPTLV 580 SGGGSTSSTS 590 SGSFEASPVE 600 PQLPSKEGPE 610 PPEEVPPPTT 620 PPVPKVEPKG 630 DGIGPTRQPP 640 SQGLGYPKYQ 650 KSLPPRFQRQ 660 QQEQLLKQQQ 670 QHQWQQHQQG 680 SAPPTPVPPS 690 PPQPVTLGAV 700 PAPQAPPPPP 710 KALYPGALGR 720 PPPMPPMNFD 730 PRWMMIPPYV 740 DPRLLQGRPP 750 LDFYPPGVHP 760 SGLVPRERSD 770 SGGSSSEPFD 780 RHAPAMLRER 790 GTPPVDPKLA 800 WVGDVFTATP 810 AEPRPLTSPL 820 RQAADEDDKG 830 MRSETPPVPP 840 PPPYLASYPG 850 FPENGAPGPP 860 ISRFPLEEPG 870 PRPLPWPPGS 880 DEVAKIQTPP 890 PKKEPPKEET 900 AQLTGPEAGR 910 KPARGVGSGG 920 QGPPPPRRES 930 RTETRWGPRP 940 GSSRRGIPPE 950 EPGAPPRRAG 960 PIKKPPPPTK 970 VEELPPKPLE 980 QGDETPKPPK 990 PDPLKITKGK 1000 LGGPKETPPN 1010 GNLSPAPRLR 1020 RDYSYERVGP 1030 TSCRGRGRGE 1040 YFARGRGFRG 1050 TYGGRGRGAR 1060 SREFRSYREF 1070 RGDDGRGGGT 1080 GGPNHPPAPR 1090 GRTASETRSE 1100 GSEYEEIPKR 1110 RRQRGSETGS 1120 ETHESDLAPS 1130 DKEAPTPKEG 1140 TLTQVPLAPP 1150 PPGAPPSPAP 1160 ARFTARGGRV 1170 FTPRGVPSRR 1180 GRGGGRPPPQ 1190 VCPGWSPPAK 1200 SLAPKKPPTG 1210 PLPPSKEPLK 1220 EKLIPGPLSP 1230 VARGGSNGGS 1240 NVGMEDGERP 1250 RRRRHGRAQQ 1260 QDKPPRFRRL 1270 KQERENAARG 1280 SEGKPSLTLP 1290 ASAPGPEEAL 1300 TTVTVAPAPR 1310 RAAAKSPDLS 1320 NQNSDQANEE 1330 WETASESSDF 1340 TSERRGDKEA 1350 PPPVLLTPKA 1360 VGTPGGGGGG 1370 AVPGISAMSR 1380 GDLSQRAKDL 1390 SKRSFSSQRP 1400 GMERQNRRPG 1410 PGGKAGSSGS 1420 SSGGGGGGPG 1430 GRTGPGRGDK 1440 RSWPSPKNRS 1450 RPPEERPPGL 1460 PLPPPPPSSS 1470 AVFRLDQVIH 1480 SNPAGIQQAL 1490 AQLSSRQGSV 1500 TAPGGHPRHK 1510 PGLPQAPQGP 1520 SPRPPTRYEP 1530 QRVNSGLSSD 1540 PHFEEPGPMV 1550 RGVGGTPRDS 1560 AGVSPFPPKR 1570 RERPPRKPEL 1580 LQEESLPPPH 1590 SSGFLGSKPE 1600 GPGPQAESRD 1610 TGTEALTPHI 1620 WNRLHTATSR 1630 KSYRPSSMEP 1640 WMEPLSPFED 1650 VAGTEMSQSD 1660 SGVDLSGDSQ 1670 VSSGPCSQRS 1680 SPDGGLKGAA 1690 EGPPKRPGGS 1700 SPLNAVPCEG 1710 PPGSEPPRRP 1720 PPAPHDGDRK 1730 ELPREQPLPP 1740 GPIGTERSQR 1750 TDRGTEPGPI 1760 RPSHRPGPPV 1770 QFGTSDKDSD 1780 LRLVVGDSLK 1790 AEKELTASVT 1800 EAIPVSRDWE 1810 LLPSAAASAE 1820 PQSKNLDSGH 1830 CVPEPSSSGQ 1840 RLYPEVFYGS 1850 AGPSSSQISG 1860 GAMDSQLHPN 1870 SGGFRPGTPS 1880 LHPYRSQPLY 1890 LPPGPAPPSA 1900 LLSGLALKGQ 1910 FLDFSTMQAT 1920 ELGKLPAGGV 1930 LYPPPSFLYS 1940 PAFCPSPLPD 1950 TSLLQVRQDL 1960 PSPSDFYSTP 1970 LQPGGQSGFL 1980 PSGAPAQQML 1990 LPMVDSQLPV 2000 VNFGSLPPAP 2010 PPAPPPLSLL 2020 PVGPALQPPS 2030 LAVRPPPAPA 2040 TRVLPSPARP 2050 FPASLGRAEL 2060 HPVELKPFQD 2070 YQKLSSNLGG 2080 PGSSRTPPTG 2090 RSFSGLNSRL 2100 KATPSTYSGV 2110 FRTQRVDLYQ 2120 QASPPDALRW 2130 IPKPWERTGP 2140 PPREGPSRRA 2150 EEPGSRGDKE PGLPPPR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0003723 RNA binding
Biological Process GO:0030154 cell differentiation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[5] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[6] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.