Search Results
Overview
| Uniprot ID | P48728 |
|---|---|
| Protein Name | Aminomethyltransferase, mitochondrial |
| Gene Name | AMT |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 313 | KVIVPQLKGRVQRRR |
| 383 | LLVEVRRKQQMAVVS |
Function
The glycine cleavage system catalyzes the degradation of glycine
Protein Sequence
10
MQRAVSVVAR
20
LGFRLQAFPP
30
ALCRPLSCAQ
40
EVLRRTPLYD
50
FHLAHGGKMV
60
AFAGWSLPVQ
70
YRDSHTDSHL
80
HTRQHCSLFD
90
VSHMLQTKIL
100
GSDRVKLMES
110
LVVGDIAELR
120
PNQGTLSLFT
130
NEAGGILDDL
140
IVTNTSEGHL
150
YVVSNAGCWE
160
KDLALMQDKV
170
RELQNQGRDV
180
GLEVLDNALL
190
ALQGPTAAQV
200
LQAGVADDLR
210
KLPFMTSAVM
220
EVFGVSGCRV
230
TRCGYTGEDG
240
VEISVPVAGA
250
VHLATAILKN
260
PEVKLAGLAA
270
RDSLRLEAGL
280
CLYGNDIDEH
290
TTPVEGSLSW
300
TLGKRRRAAM
310
DFPGAKVIVP
320
QLKGRVQRRR
330
VGLMCEGAPM
340
RAHSPILNME
350
GTKIGTVTSG
360
CPSPSLKKNV
370
AMGYVPCEYS
380
RPGTMLLVEV
390
RRKQQMAVVS
400
KMPFVPTNYY
TLK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005960 | glycine cleavage complex |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004047 | aminomethyltransferase activity |
| Molecular Function | GO:0008483 | transaminase activity |
| Biological Process | GO:0006546 | glycine catabolic process |
| Biological Process | GO:0019464 | glycine decarboxylation via glycine cleavage system |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.