Overview
| Uniprot ID | P48729 |
|---|
| Protein Name | Casein kinase I isoform alpha |
|---|
| Gene Name | CSNK1A1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 8 |
MASSSGSKAEFIVGG |
Function
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). It can phosphorylate a large number of proteins (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). Participates in Wnt signaling (PubMed:11955436). Phosphorylates CTNNB1 at 'Ser-45' (PubMed:11955436). May phosphorylate PER1 and PER2 (By similarity). May play a role in segregating chromosomes during mitosis (PubMed:1409656). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688). Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor (PubMed:22017875, PubMed:22017877). Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity)
Protein Sequence
10
MASSSGSKAE
20
FIVGGKYKLV
30
RKIGSGSFGD
40
IYLAINITNG
50
EEVAVKLESQ
60
KARHPQLLYE
70
SKLYKILQGG
80
VGIPHIRWYG
90
QEKDYNVLVM
100
DLLGPSLEDL
110
FNFCSRRFTM
120
KTVLMLADQM
130
ISRIEYVHTK
140
NFIHRDIKPD
150
NFLMGIGRHC
160
NKLFLIDFGL
170
AKKYRDNRTR
180
QHIPYREDKN
190
LTGTARYASI
200
NAHLGIEQSR
210
RDDMESLGYV
220
LMYFNRTSLP
230
WQGLKAATKK
240
QKYEKISEKK
250
MSTPVEVLCK
260
GFPAEFAMYL
270
NYCRGLRFEE
280
APDYMYLRQL
290
FRILFRTLNH
300
QYDYTFDWTM
310
LKQKAAQQAA
320
SSSGQGQQAQ
330
TPTGKQTDKT
KSNMKGF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030877 |
beta-catenin destruction complex |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0036064 |
ciliary basal body |
| Cellular Component |
GO:0005929 |
cilium |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0000776 |
kinetochore |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0016607 |
nuclear speck |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005819 |
spindle |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0004672 |
protein kinase activity |
| Molecular Function |
GO:0106310 |
protein serine kinase activity |
| Molecular Function |
GO:0004674 |
protein serine/threonine kinase activity |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0007166 |
cell surface receptor signaling pathway |
| Biological Process |
GO:0031670 |
cellular response to nutrient |
| Biological Process |
GO:0007030 |
Golgi organization |
| Biological Process |
GO:0045104 |
intermediate filament cytoskeleton organization |
| Biological Process |
GO:0090090 |
negative regulation of canonical Wnt signaling pathway |
| Biological Process |
GO:1900226 |
negative regulation of NLRP3 inflammasome complex assembly |
| Biological Process |
GO:0032436 |
positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| Biological Process |
GO:0035025 |
positive regulation of Rho protein signal transduction |
| Biological Process |
GO:1904263 |
positive regulation of TORC1 signaling |
| Biological Process |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process |
GO:0006468 |
protein phosphorylation |
| Biological Process |
GO:0007165 |
signal transduction |
| Biological Process |
GO:0019082 |
viral protein processing |
| Biological Process |
GO:0016055 |
Wnt signaling pathway |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.