Search Results

Overview

Uniprot IDP48735
Protein NameIsocitrate dehydrogenase [NADP], mitochondrial
Gene NameIDH2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
106 DSALATQKYSVAVKC
112 QKYSVAVKCATITPD
133 FKLKKMWKSPNGTIR
155 FREPIICKNIPRLVP
166 RLVPGWTKPITIGRH
180 HAHGDQYKATDFVAD
199 FKMVFTPKDGSGVKE
243 FQYAIQKKWPLYMST
256 STKNTILKAYDGRFK
263 KAYDGRFKDIFQEIF
272 IFQEIFDKHYKTDFD
275 EIFDKHYKTDFDKNK
280 HYKTDFDKNKIWYEH
282 KTDFDKNKIWYEHRL
340 VLVCPDGKTIEAEAA
360 RHYREHQKGRPTSTN
384 RGLEHRGKLDGNQDL
413 VESGAMTKDLAGCIH
426 IHGLSNVKLNEHFLN
45 HYADKRIKVAKPVVE
48 DKRIKVAKPVVEMDG
67 RIIWQFIKEKLILPH
69 IWQFIKEKLILPHVD

Function

Plays a role in intermediary metabolism and energy production (PubMed:19228619, PubMed:22416140). It may tightly associate or interact with the pyruvate dehydrogenase complex (PubMed:19228619, PubMed:22416140)

Protein Sequence

10 MAGYLRVVRS 20 LCRASGSRPA 30 WAPAALTAPT 40 SQEQPRRHYA 50 DKRIKVAKPV 60 VEMDGDEMTR 70 IIWQFIKEKL 80 ILPHVDIQLK 90 YFDLGLPNRD 100 QTDDQVTIDS 110 ALATQKYSVA 120 VKCATITPDE 130 ARVEEFKLKK 140 MWKSPNGTIR 150 NILGGTVFRE 160 PIICKNIPRL 170 VPGWTKPITI 180 GRHAHGDQYK 190 ATDFVADRAG 200 TFKMVFTPKD 210 GSGVKEWEVY 220 NFPAGGVGMG 230 MYNTDESISG 240 FAHSCFQYAI 250 QKKWPLYMST 260 KNTILKAYDG 270 RFKDIFQEIF 280 DKHYKTDFDK 290 NKIWYEHRLI 300 DDMVAQVLKS 310 SGGFVWACKN 320 YDGDVQSDIL 330 AQGFGSLGLM 340 TSVLVCPDGK 350 TIEAEAAHGT 360 VTRHYREHQK 370 GRPTSTNPIA 380 SIFAWTRGLE 390 HRGKLDGNQD 400 LIRFAQMLEK 410 VCVETVESGA 420 MTKDLAGCIH 430 GLSNVKLNEH 440 FLNTTDFLDT 450 IKSNLDRALG RQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005777 peroxisome
Molecular Function GO:0004450 isocitrate dehydrogenase (NADP+) activity
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0051287 NAD binding
Biological Process GO:0006103 2-oxoglutarate metabolic process
Biological Process GO:0005975 carbohydrate metabolic process
Biological Process GO:0006097 glyoxylate cycle
Biological Process GO:0006102 isocitrate metabolic process
Biological Process GO:0006741 NADP+ biosynthetic process
Biological Process GO:0006739 NADP+ metabolic process
Biological Process GO:1903976 negative regulation of glial cell migration
Biological Process GO:0060253 negative regulation of glial cell proliferation
Biological Process GO:1904465 negative regulation of matrix metallopeptidase secretion
Biological Process GO:0006099 tricarboxylic acid cycle

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.