Search Results
Overview
| Uniprot ID | P48739 |
|---|---|
| Protein Name | Phosphatidylinositol transfer protein beta isoform |
| Gene Name | PITPNB |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 65 | THKIYHLKSKVPAFV |
Function
Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (PubMed:10531358, PubMed:18636990, PubMed:20332109). Also catalyzes the transfer of sphingomyelin (By similarity). Required for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum; phosphatidylinositol and phosphatidylcholine transfer activity is essential for this function (PubMed:20332109)
Protein Sequence
10
MVLIKEFRVV
20
LPCSVQEYQV
30
GQLYSVAEAS
40
KNETGGGEGI
50
EVLKNEPYEK
60
DGEKGQYTHK
70
IYHLKSKVPA
80
FVRMIAPEGS
90
LVFHEKAWNA
100
YPYCRTIVTN
110
EYMKDDFFIK
120
IETWHKPDLG
130
TLENVHGLDP
140
NTWKTVEIVH
150
IDIADRSQVE
160
PADYKADEDP
170
ALFQSVKTKR
180
GPLGPNWKKE
190
LANSPDCPQM
200
CAYKLVTIKF
210
KWWGLQSKVE
220
NFIQKQEKRI
230
FTNFHRQLFC
240
WIDKWIDLTM
250
EDIRRMEDET
260
QKELETMRKR
270
GSVRGTSAAD
V
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000139 | Golgi membrane |
| Molecular Function | GO:0031210 | phosphatidylcholine binding |
| Molecular Function | GO:0120019 | phosphatidylcholine transfer activity |
| Molecular Function | GO:0008525 | phosphatidylcholine transporter activity |
| Molecular Function | GO:0035091 | phosphatidylinositol binding |
| Molecular Function | GO:0008526 | phosphatidylinositol transfer activity |
| Molecular Function | GO:0120014 | phospholipid transfer activity |
| Molecular Function | GO:0140338 | sphingomyelin transfer activity |
| Biological Process | GO:0006629 | lipid metabolic process |
| Biological Process | GO:0006997 | nucleus organization |
| Biological Process | GO:0015914 | phospholipid transport |
| Biological Process | GO:0006890 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.