Search Results
Overview
| Uniprot ID | P48768 |
|---|---|
| Protein Name | Sodium/calcium exchanger 2 |
| Gene Name | Slc8a2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 348 | YALLHQQKSRAFYRI |
| 634 | NQGDGDRKLTAEEEE |
Function
Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:8021246, PubMed:9486131). Contributes to cellular Ca(2+) homeostasis in excitable cells (By similarity). Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (By similarity). Plays a role in regulating urinary Ca(2+) and Na(+) excretion (By similarity)
Protein Sequence
10
MAPLALVGVA
20
LLLGAPHCLG
30
EATPTPSLPP
40
PPANDSDASP
50
GGCQGSYRCQ
60
PGVLLPVWEP
70
DDPSLGDKAA
80
RAVVYFVAMV
90
YMFLGLSIIA
100
DRFMASIEVI
110
TSKEKEITIT
120
KANGETSVGT
130
VRIWNETVSN
140
LTLMALGSSA
150
PEILLSVIEV
160
CGHNFQAGEL
170
GPGTIVGSAA
180
FNMFVVIAVC
190
VYVIPAGESR
200
KIKHLRVFFV
210
TASWSIFAYV
220
WLYLILAVFS
230
PGVVQVWEAL
240
LTLVFFPVCV
250
VFAWMADKRL
260
LFYKYVYKRY
270
RTDPRSGIII
280
GAEGDPPKSI
290
ELDGTFVGTE
300
VPGELGALGT
310
GPAEARELDA
320
SRREVIQILK
330
DLKQKHPDKD
340
LEQLVGIAKY
350
YALLHQQKSR
360
AFYRIQATRL
370
MTGAGNVLRR
380
HAADAARRPG
390
ANDGAPDDED
400
DGASRIFFEP
410
SLYHCLENCG
420
SVLLSVACQG
430
GEGNSTFYVD
440
YRTEDGSAKA
450
GSDYEYSEGT
460
LVFKPGETQK
470
ELRIGIIDDD
480
IFEEDEHFFV
490
RLLNLRVGDA
500
QGMFEPDGGG
510
RPKGRLVAPL
520
LATVTILDDD
530
HAGIFSFQDR
540
LLHVSECMGT
550
VDVRVVRSSG
560
ARGTVRLPYR
570
TVDGTARGGG
580
VHYEDACGEL
590
EFGDDETMKT
600
LQVKIVDDEE
610
YEKKDNFFIE
620
LGQPQWLKRG
630
ISALLLNQGD
640
GDRKLTAEEE
650
EAQRIAEMGK
660
PVLGENCRLE
670
VIIEESYDFK
680
NTVDKLIKKT
690
NLALVIGTHS
700
WREQFLEAVT
710
VSAGDEEEDE
720
DGSREERLPS
730
CFDYVMHFLT
740
VFWKVLFACL
750
PPTEYCHGWA
760
CFGVCILVIG
770
LLTALIGDLA
780
SHFGCTVGLK
790
DSVNAVVFVA
800
LGTSIPDTFA
810
SKVAALQDQC
820
ADASIGNVTG
830
SNAVNVFLGL
840
GVAWSVAAVY
850
WAVQGRPFEV
860
RTGTLAFSVT
870
LFTVFAFVGI
880
AVLLYRRRPH
890
IGGELGGPRG
900
PKLATTALFL
910
GLWFLYILFA
920
SLEAYCHIRG
F
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0043679 | axon terminus |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0042995 | cell projection |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0045211 | postsynaptic membrane |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:0042383 | sarcolemma |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0015085 | calcium ion transmembrane transporter activity |
| Molecular Function | GO:1905060 | calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration |
| Molecular Function | GO:0005432 | calcium:sodium antiporter activity |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0015081 | sodium ion transmembrane transporter activity |
| Biological Process | GO:1990034 | calcium ion export across plasma membrane |
| Biological Process | GO:0098703 | calcium ion import across plasma membrane |
| Biological Process | GO:0070588 | calcium ion transmembrane transport |
| Biological Process | GO:0060402 | calcium ion transport into cytosol |
| Biological Process | GO:0007154 | cell communication |
| Biological Process | GO:0050890 | cognition |
| Biological Process | GO:0006874 | intracellular calcium ion homeostasis |
| Biological Process | GO:0007612 | learning |
| Biological Process | GO:0007611 | learning or memory |
| Biological Process | GO:0060291 | long-term synaptic potentiation |
| Biological Process | GO:0007613 | memory |
| Biological Process | GO:0098815 | modulation of excitatory postsynaptic potential |
| Biological Process | GO:0070050 | neuron cellular homeostasis |
| Biological Process | GO:1902533 | positive regulation of intracellular signal transduction |
| Biological Process | GO:0099608 | regulation of action potential firing pattern |
| Biological Process | GO:0106056 | regulation of calcineurin-mediated signaling |
| Biological Process | GO:0051480 | regulation of cytosolic calcium ion concentration |
| Biological Process | GO:0010468 | regulation of gene expression |
| Biological Process | GO:0048172 | regulation of short-term neuronal synaptic plasticity |
| Biological Process | GO:0002931 | response to ischemia |
| Biological Process | GO:0033280 | response to vitamin D |
| Biological Process | GO:0035725 | sodium ion transmembrane transport |
| Biological Process | GO:0006814 | sodium ion transport |
| Biological Process | GO:0050808 | synapse organization |
| Biological Process | GO:0021537 | telencephalon development |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.