Search Results
Overview
| Uniprot ID | P48787 |
|---|---|
| Protein Name | Troponin I, cardiac muscle |
| Gene Name | Tnni3 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 107 | QLHARVDKVDEERYD |
| 118 | ERYDVEAKVTKNITE |
| 121 | DVEAKVTKNITEIAD |
| 194 | REVGDWRKNIDALSG |
| 37 | YATEPHAKKKSKISA |
Function
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity
Protein Sequence
10
MADESSDAAG
20
EPQPAPAPVR
30
RRSSANYRAY
40
ATEPHAKKKS
50
KISASRKLQL
60
KTLMLQIAKQ
70
EMEREAEERR
80
GEKGRVLRTR
90
CQPLELDGLG
100
FEELQDLCRQ
110
LHARVDKVDE
120
ERYDVEAKVT
130
KNITEIADLT
140
QKIYDLRGKF
150
KRPTLRRVRI
160
SADAMMQALL
170
GTRAKESLDL
180
RAHLKQVKKE
190
DIEKENREVG
200
DWRKNIDALS
210
GMEGRKKKFE
G
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0097512 | cardiac myofibril |
| Cellular Component | GO:1990584 | cardiac Troponin complex |
| Cellular Component | GO:0043292 | contractile muscle fiber |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0030016 | myofibril |
| Cellular Component | GO:0030017 | sarcomere |
| Cellular Component | GO:0005861 | troponin complex |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0019855 | calcium channel inhibitor activity |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0030172 | troponin C binding |
| Molecular Function | GO:0031014 | troponin T binding |
| Biological Process | GO:0060048 | cardiac muscle contraction |
| Biological Process | GO:0060047 | heart contraction |
| Biological Process | GO:0007507 | heart development |
| Biological Process | GO:0006874 | intracellular calcium ion homeostasis |
| Biological Process | GO:0030049 | muscle filament sliding |
| Biological Process | GO:0032780 | negative regulation of ATP-dependent activity |
| Biological Process | GO:0010882 | regulation of cardiac muscle contraction by calcium ion signaling |
| Biological Process | GO:0006937 | regulation of muscle contraction |
| Biological Process | GO:0006940 | regulation of smooth muscle contraction |
| Biological Process | GO:0001980 | regulation of systemic arterial blood pressure by ischemic conditions |
| Biological Process | GO:0003009 | skeletal muscle contraction |
| Biological Process | GO:0006941 | striated muscle contraction |
| Biological Process | GO:0001570 | vasculogenesis |
| Biological Process | GO:0055010 | ventricular cardiac muscle tissue morphogenesis |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.