Search Results
Overview
| Uniprot ID | P49006 |
|---|---|
| Protein Name | MARCKS-related protein |
| Gene Name | MARCKSL1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 95 | KKKKFSFKKPFKLSG |
| 99 | FSFKKPFKLSGLSFK |
Function
Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity)
Protein Sequence
10
MGSQSSKAPR
20
GDVTAEEAAG
30
ASPAKANGQE
40
NGHVKSNGDL
50
SPKGEGESPP
60
VNGTDEAAGA
70
TGDAIEPAPP
80
SQGAEAKGEV
90
PPKETPKKKK
100
KFSFKKPFKL
110
SGLSFKRNRK
120
EGGGDSSASS
130
PTEEEQEQGE
140
IGACSDEGTA
150
QEGKAAATPE
160
SQEPQAKGAE
170
ASAASEEEAG
180
PQATEPSTPS
190
GPESGPTPAS
AEQNE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0005516 | calmodulin binding |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0007417 | central nervous system development |
Reference
PMID: N/A