Search Results
Overview
| Uniprot ID | P49023 |
|---|---|
| Protein Name | Paxillin |
| Gene Name | PXN |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 199 | GKAGPLTKEKPKRNG |
| 355 | LGVATVAKGVCGACK |
Function
Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion
Protein Sequence
10
MDDLDALLAD
20
LESTTSHISK
30
RPVFLSEETP
40
YSYPTGNHTY
50
QEIAVPPPVP
60
PPPSSEALNG
70
TILDPLDQWQ
80
PSSSRFIHQQ
90
PQSSSPVYGS
100
SAKTSSVSNP
110
QDSVGSPCSR
120
VGEEEHVYSF
130
PNKQKSAEPS
140
PTVMSTSLGS
150
NLSELDRLLL
160
ELNAVQHNPP
170
GFPADEANSS
180
PPLPGALSPL
190
YGVPETNSPL
200
GGKAGPLTKE
210
KPKRNGGRGL
220
EDVRPSVESL
230
LDELESSVPS
240
PVPAITVNQG
250
EMSSPQRVTS
260
TQQQTRISAS
270
SATRELDELM
280
ASLSDFKIQG
290
LEQRADGERC
300
WAAGWPRDGG
310
RSSPGGQDEG
320
GFMAQGKTGS
330
SSPPGGPPKP
340
GSQLDSMLGS
350
LQSDLNKLGV
360
ATVAKGVCGA
370
CKKPIAGQVV
380
TAMGKTWHPE
390
HFVCTHCQEE
400
IGSRNFFERD
410
GQPYCEKDYH
420
NLFSPRCYYC
430
NGPILDKVVT
440
ALDRTWHPEH
450
FFCAQCGAFF
460
GPEGFHEKDG
470
KAYCRKDYFD
480
MFAPKCGGCA
490
RAILENYISA
500
LNTLWHPECF
510
VCRECFTPFV
520
NGSFFEHDGQ
530
PYCEVHYHER
540
RGSLCSGCQK
550
PITGRCITAM
560
AKKFHPEHFV
570
CAFCLKQLNK
580
GTFKEQNDKP
590
YCQNCFLKLF
C
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0005875 | microtubule associated complex |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0001725 | stress fiber |
| Molecular Function | GO:0008013 | beta-catenin binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0038191 | neuropilin binding |
| Molecular Function | GO:0019903 | protein phosphatase binding |
| Molecular Function | GO:0017166 | vinculin binding |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0016477 | cell migration |
| Biological Process | GO:0034614 | cellular response to reactive oxygen species |
| Biological Process | GO:0043542 | endothelial cell migration |
| Biological Process | GO:0060396 | growth hormone receptor signaling pathway |
| Biological Process | GO:0051496 | positive regulation of stress fiber assembly |
| Biological Process | GO:0007172 | signal complex assembly |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0034446 | substrate adhesion-dependent cell spreading |
| Biological Process | GO:0007179 | transforming growth factor beta receptor signaling pathway |
Reference
[1] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.