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Overview

Uniprot IDP49189
Protein Name4-trimethylaminobutyraldehyde dehydrogenase
Gene NameALDH9A1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
298 GTRVFVQKEILDKFT
30 ADASGTEKAFEPATG
303 VQKEILDKFTEEVVK
310 KFTEEVVKQTQRIKI
316 VKQTQRIKIGDPLLE
344 ERVLGFVKVAKEQGA
347 LGFVKVAKEQGAKVL
352 VAKEQGAKVLCGGDI
366 IYVPEDPKLKDGYYM
49 TFTCSGEKEVNLAVQ
59 NLAVQNAKAAFKIWS
68 AFKIWSQKSGMERCR

Function

Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. Catalyzes the oxidation of aldehydes arising from biogenic amines and polyamines

Protein Sequence

10 MSTGTFVVSQ 20 PLNYRGGARV 30 EPADASGTEK 40 AFEPATGRVI 50 ATFTCSGEKE 60 VNLAVQNAKA 70 AFKIWSQKSG 80 MERCRILLEA 90 ARIIREREDE 100 IATMECINNG 110 KSIFEARLDI 120 DISWQCLEYY 130 AGLAASMAGE 140 HIQLPGGSFG 150 YTRREPLGVC 160 VGIGAWNYPF 170 QIASWKSAPA 180 LACGNAMVFK 190 PSPFTPVSAL 200 LLAEIYSEAG 210 VPPGLFNVVQ 220 GGAATGQFLC 230 QHPDVAKVSF 240 TGSVPTGMKI 250 MEMSAKGIKP 260 VTLELGGKSP 270 LIIFSDCDMN 280 NAVKGALMAN 290 FLTQGQVCCN 300 GTRVFVQKEI 310 LDKFTEEVVK 320 QTQRIKIGDP 330 LLEDTRMGPL 340 INRPHLERVL 350 GFVKVAKEQG 360 AKVLCGGDIY 370 VPEDPKLKDG 380 YYMRPCVLTN 390 CRDDMTCVKE 400 EIFGPVMSIL 410 SFDTEAEVLE 420 RANDTTFGLA 430 AGVFTRDIQR 440 AHRVVAELQA 450 GTCFINNYNV 460 SPVELPFGGY 470 KKSGFGRENG 480 RVTIEYYSQL 490 KTVCVEMGDV ESAF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0047105 4-trimethylammoniobutyraldehyde dehydrogenase activity
Molecular Function GO:0140087 acetaldehyde dehydrogenase (NAD+) activity
Molecular Function GO:0004029 aldehyde dehydrogenase (NAD+) activity
Molecular Function GO:0019145 aminobutyraldehyde dehydrogenase (NAD+) activity
Molecular Function GO:0018467 formaldehyde dehydrogenase (NAD+) activity
Molecular Function GO:0036094 small molecule binding
Biological Process GO:0006081 aldehyde metabolic process
Biological Process GO:0045329 carnitine biosynthetic process
Biological Process GO:0051289 protein homotetramerization
Biological Process GO:0042429 serotonin catabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.