Search Results
Overview
| Uniprot ID | P49242 |
|---|---|
| Protein Name | Small ribosomal subunit protein eS1 |
| Gene Name | Rps3a |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 144 | LFCVGFTKKRNNQIR |
| 152 | KRNNQIRKTSYAQHQ |
| 167 | QVRQIRKKMMEIMTR |
| 182 | EVQTNDLKEVVNKLI |
| 187 | DLKEVVNKLIPDSIG |
| 20 | GKKGAKKKVVDPFSK |
| 220 | RKVKMLKKPKFELGK |
| 222 | VKMLKKPKFELGKLM |
| 249 | TGDETGAKVERADGY |
| 28 | VVDPFSKKDWYDVKA |
| 46 | FNIRNIGKTLVTRTQ |
| 56 | VTRTQGTKIASDGLK |
| 63 | KIASDGLKGRVFEVS |
| 85 | EVAFRKFKLITEDVQ |
Function
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0022626 | cytosolic ribosome |
| Cellular Component | GO:0022627 | cytosolic small ribosomal subunit |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Cellular Component | GO:0015935 | small ribosomal subunit |
| Cellular Component | GO:0032040 | small-subunit processome |
| Molecular Function | GO:0048027 | mRNA 5'-UTR binding |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0003735 | structural constituent of ribosome |
| Molecular Function | GO:0031369 | translation initiation factor binding |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0048146 | positive regulation of fibroblast proliferation |
| Biological Process | GO:0045727 | positive regulation of translation |
| Biological Process | GO:0045471 | response to ethanol |
| Biological Process | GO:0042274 | ribosomal small subunit biogenesis |
| Biological Process | GO:0006412 | translation |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.