Search Results
Overview
| Uniprot ID | P49257 |
|---|---|
| Protein Name | Protein ERGIC-53 |
| Gene Name | LMAN1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 197 | CQRDFRNKPYPVRAK |
| 346 | NRIHLEIKQLNRQLD |
| 447 | KEHLHIVKRDIDNLV |
| 87 | IRVAPSLKSQRGSVW |
Function
Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins
Protein Sequence
10
MAGSRQRGLR
20
ARVRPLFCAL
30
LLSLGRFVRG
40
DGVGGDPAVA
50
LPHRRFEYKY
60
SFKGPHLVQS
70
DGTVPFWAHA
80
GNAIPSSDQI
90
RVAPSLKSQR
100
GSVWTKTKAA
110
FENWEVEVTF
120
RVTGRGRIGA
130
DGLAIWYAEN
140
QGLEGPVFGS
150
ADLWNGVGIF
160
FDSFDNDGKK
170
NNPAIVIIGN
180
NGQIHYDHQN
190
DGASQALASC
200
QRDFRNKPYP
210
VRAKITYYQN
220
TLTVMINNGF
230
TPDKNDYEFC
240
AKVENMIIPA
250
QGHFGISAAT
260
GGLADDHDVL
270
SFLTFQLTEP
280
GKEPPTPDKE
290
ISEKEKEKYQ
300
EEFEHFQQEL
310
DKKKEEFQKG
320
HPDLQGQPAE
330
EIFESVGDRE
340
LRQVFEGQNR
350
IHLEIKQLNR
360
QLDMILDEQR
370
RYVSSLTEEI
380
SKRGAGMPGQ
390
HGQITQQELD
400
TVVKTQHEIL
410
RQVNEMKNSM
420
SETVRLVSGM
430
QHPGSAGGVY
440
ETTQHFIDIK
450
EHLHIVKRDI
460
DNLVQRNMPS
470
NEKPKCPELP
480
PFPSCLSTVH
490
FIIFVVVQTV
500
LFIGYIMYRS
510
QQEAAAKKFF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030134 | COPII-coated ER to Golgi transport vesicle |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
| Cellular Component | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane |
| Cellular Component | GO:0012507 | ER to Golgi transport vesicle membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0030017 | sarcomere |
| Molecular Function | GO:0005537 | D-mannose binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:0007596 | blood coagulation |
| Biological Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| Biological Process | GO:0007030 | Golgi organization |
| Biological Process | GO:1903215 | negative regulation of protein targeting to mitochondrion |
| Biological Process | GO:0010638 | positive regulation of organelle organization |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0015031 | protein transport |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.